2739805-63-9
Chemical Structure
NT1-O12B
- CAS No.: 2739805-63-9
- Formula:C36H60N2O4S4
- Molecular Weight:713.13
IUPAC Name: bis(2-(octyldisulfanyl)ethyl) 3,3'-((2-(1H-indol-3-yl)ethyl)azanediyl)dipropionate
InChIKey: CUQWZMJHMHGHEV-UHFFFAOYSA-N
SMILES: CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O
Biological Activity: NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination[1].
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NT1-O12B | 97.35% | NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. | ||||||||||||||||||||
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Keywords
