2. Metabolic Enzyme/Protease
  3. Liposome
  4. PBA-Q76-O16B

PBA-Q76-O16B is a lipid that cannot cross the blood-brain barrier on its own, but can mediate cargo delivery into the brains of mice when blended with NT1 lipids. After forming stable small-sized lipid nanoparticles with NT1-O12B, PBA-Q76-O16B delivers drugs into the brains of mice. When formulated into lipid nanoparticles with NT1-O14B, PBA-Q76-O16B delivers (-27) GFP-Cre recombinase into mouse brain cells, driving functional gene recombination in multiple brain regions. PBA-Q76-O16B can be used in studies related to lipid nanoparticles (LNPs).

For research use only. We do not sell to patients.

PBA-Q76-O16B

PBA-Q76-O16B Chemical Structure

CAS No. : 3027931-27-4

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PBA-Q76-O16B Related Antibodies

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Description

PBA-Q76-O16B is a lipid that cannot cross the blood-brain barrier on its own, but can mediate cargo delivery into the brains of mice when blended with NT1 lipids. After forming stable small-sized lipid nanoparticles with NT1-O12B, PBA-Q76-O16B delivers drugs into the brains of mice. When formulated into lipid nanoparticles with NT1-O14B, PBA-Q76-O16B delivers (-27) GFP-Cre recombinase into mouse brain cells, driving functional gene recombination in multiple brain regions. PBA-Q76-O16B can be used in studies related to lipid nanoparticles (LNPs)[1][2].

In Vivo

PBA-Q76-O16B (1 mg/kg; i.v.; single injection) in 3:7 weight ratio with NT1-O12B LNPs delivers DiR to the mouse brain with 4.5-fold higher fluorescence intensity than pure NT1-O12B LNPs[1].
PBA-Q76-O16B (50 μg (-27)GFP-Cre per injection; i.v.; four injections spaced 5 days apart) in 3:7 weight ratio with NT1-O14B LNPs delivers functional (-27)GFP-Cre protein to neuronal cells across multiple mouse brain regions, inducing Cre-mediated gene recombination[1].
PBA-Q76-O16B (3:7 weight ratio with NT1-O12B; i.v.; single dose), when mixed with NT1-O12B as part of a nanoparticle carrier, facilitates efficient cargo delivery across the blood-brain barrier in healthy BALB/C mice[2].
PBA-Q76-O16B (3:7 weight ratio with NT1-O12B; i.v.; every 2 weeks; 8 weeks), when mixed with NT1-O12B at a 3:7 weight ratio as part of SSK1-NPs, enables efficient delivery of SSK1 to the brain of 3xTg AD mice, leading to significant elimination of senescent cells, reduction of Aβ accumulation, improvement of cognitive function, and an excellent safety profile[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

914.27

Formula

C47H86BN2O6S4+
CAS No.
SMILES

CCCCCCCCCCCCSSCCOC(CC[N+](CCN1CCCC1)(CC2=CC=C(B(O)O)C=C2)CCC(OCCSSCCCCCCCCCCCC)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PBA-Q76-O16B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBA-Q76-O16B3027931-27-4Liposomemouse brainblood-brain barrierlipid nanoparticlesNT1-lipidoidsNT1-O14Balzheimer’s diseaseNT1-O12BSSK1DiRamphotericin BInhibitorinhibitorinhibit

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