PBA-Q76-O16B

PBA-Q76-O16B (1 mg/kg; i.v.; single injection) in 3:7 weight ratio with NT1-O12B LNPs delivers DiR to the mouse brain with 4.5-fold higher fluorescence intensity than pure NT1-O12B LNPs^[1].
PBA-Q76-O16B (50 μg (-27)GFP-Cre per injection; i.v.; four injections spaced 5 days apart) in 3:7 weight ratio with NT1-O14B LNPs delivers functional (-27)GFP-Cre protein to neuronal cells across multiple mouse brain regions, inducing Cre-mediated gene recombination^[1].
PBA-Q76-O16B (3:7 weight ratio with NT1-O12B; i.v.; single dose), when mixed with NT1-O12B as part of a nanoparticle carrier, facilitates efficient cargo delivery across the blood-brain barrier in healthy BALB/C mice^[2].
PBA-Q76-O16B (3:7 weight ratio with NT1-O12B; i.v.; every 2 weeks; 8 weeks), when mixed with NT1-O12B at a 3:7 weight ratio as part of SSK1-NPs, enables efficient delivery of SSK1 to the brain of 3xTg AD mice, leading to significant elimination of senescent cells, reduction of A^β accumulation, improvement of cognitive function, and an excellent safety profile^[2].