Search Result

Results for "

nucleotide+synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (1) Akt (1) Antibiotic (3) Antifolate (7) Apoptosis (3) Arenavirus (1) Atg8/LC3 (1) ATP Synthase (3) Autophagy (2) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (3) CDK (2) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (9) Drug Intermediate (2) Environmental Pollutants (1) Fungal (1) Guanylate Cyclase (1) Isotope-Labeled Compounds (5) mGluR (1) Nucleoside Antimetabolite/Analog (1) Parasite (7) PARP (2) Reference Standards (3) STAT (7)
By Research Areas:	Cancer (12) Infection (15) Metabolic Disease (6)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13560

AVN-944 5 Publications Verification VX-944	Arenavirus DNA/RNA Synthesis Apoptosis Caspase Bcl-2 Family	Infection Cancer
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research .

HY-175282

ASX-173	Apoptosis Caspase CDK PARP Akt Autophagy Atg8/LC3	Cancer
ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC₅₀ = 0.113 μM, K_i = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers .

HY-B1162

Sulisobenzone 1 Publications Verification Benzophenone-4	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

HY-138354A

Pyrroline-5-carboxylate sodium	Drug Intermediate	Infection
Pyrroline-5-carboxylate sodium is a key intermediate in proline anabolism and catabolism. Pyrroline-5-carboxylate sodium plays important roles in plant defense against pathogen invasion, as well as in redox regulation, nucleotide synthesis and other processes in animal cells .

HY-12784A

Cycloguanil hydrochloride 3 Publications Verification Chlorguanide triazine hydrochloride	Antifolate Parasite DNA/RNA Synthesis STAT	Infection Cancer
Cycloguanil (Chlorguanide triazine) hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-B0614B

Mafenide hydrochloride	Bacterial Antibiotic	Infection
Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide hydrochloride shows activity against both Gram-positive and Gram-negative organisms, including *Pseudomonas aeruginosa, via inhibition of nucleotide synthesis* .

HY-B0614

Mafenide	Bacterial Antibiotic	Infection
Mafenide is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide shows activity against both Gram-positive and Gram-negative organisms, including *Pseudomonas aeruginosa, via inhibition of nucleotide synthesis* .

HY-107547

BPIPP	Guanylate Cyclase Adenylate Cyclase	Metabolic Disease
BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Fungal	Infection
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-138354

Pyrroline-5-carboxylate	Drug Intermediate	Infection
Pyrroline-5-carboxylate is a key intermediate in proline anabolism and catabolism. Pyrroline-5-carboxylate plays important roles in plant defense against pathogen invasion, as well as in redox regulation, nucleotide synthesis and other processes in animal cells .

HY-10250

Triciribine phosphate TCN-P	ATP Synthase	Metabolic Disease Cancer
Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .

HY-12784

Cycloguanil Chlorguanide triazine	Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil (Chlorguanide triazine) is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784AR

Cycloguanil hydrochloride (Standard) Chlorguanide triazine hydrochloride (Standard)	Reference Standards Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil hydrochloride (Standard) is the analytical standard of Cycloguanil hydrochloride (HY-12784A). This product is intended for research and analytical applications. Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-139658

D-Xylofuranose, 1,2,3,5-tetraacetate	DNA/RNA Synthesis	Others
D-Xylofuranose, 1,2,3,5-tetraacetate is the raw material for nucleotides synthesis .

HY-N7517

Adenosine 5′-monophosphoramidate sodium	Nucleoside Antimetabolite/Analog	Others
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP .

HY-10250A

Triciribine phosphate sodium TCN-P sodium	ATP Synthase	Metabolic Disease Cancer
Triciribine phosphate sodium inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate sodium also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .

HY-B0614BR

Mafenide hydrochloride (Standard)	Reference Standards Bacterial Antibiotic	Infection
Mafenide (hydrochloride) (Standard) is the analytical standard of Mafenide (hydrochloride). This product is intended for research and analytical applications. Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide hydrochloride shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis[1][2].

HY-105916

NSC 303861	mGluR	Cancer
NSC 303861 is an L-glutamine receptor antagonist. NSC 303861 selectively inhibits glutamine dependent enzymes in purine nucleotide synthesis without affecting pyrimidine synthase. NSC 303861 has significant cytotoxicity against liver cancer 3924A cells (LC₅₀ = 6 µM). NSC 303861 can be used for cancer research .

HY-B1162R

Sulisobenzone (Standard) Benzophenone-4 (Standard)	Biochemical Assay Reagents Reference Standards	Metabolic Disease
Sulisobenzone (Benzophenone-4) (Standard) is the analytical standard of Sulisobenzone (HY-B1162). This product is intended for research and analytical applications. Sulisobenzone is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

HY-10250S1

Triciribine phosphate-d3 TCN-P-d₃	Isotope-Labeled Compounds ATP Synthase	Metabolic Disease
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-12784S

Cycloguanil-d6 1 Publications Verification Chlorguanide triazine-d₆	Isotope-Labeled Compounds Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil-d₆ (Chlorguanide triazine-d₆) is the deuterium labeled Cycloguanil (HY-12784). Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784AS

Cycloguanil-d4 hydrochloride Chlorguanide triazine-d4 hydrochloride	Isotope-Labeled Compounds Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil-d₄ (Chlorguanide triazine-d₄) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784AS1

Cycloguanil-d6 hydrochloride Chlorguanide triazine-d6 hydrochloride	Isotope-Labeled Compounds Antifolate DNA/RNA Synthesis STAT Parasite	Infection
Cycloguanil-d₆ (Chlorguanide triazine-d₆) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784S1

Cycloguanil-d6 nitrate Chlorguanide triazine-d₆ nitrate	Isotope-Labeled Compounds Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil-d₆ (Chlorguanide triazine-d₆) nitrate is the deuterium labeled Cycloguanil nitrate. Cycloguanil nitrate is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil nitrate blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil nitrate inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil nitrate also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-181100

DHFR-IN-26	Dihydrofolate reductase (DHFR) Bacterial	Infection
DHFR-IN-26 is an Escherichia coli dihydrofolate reductase (ecDHFR) inhibitor with an IC₅₀ of 0.75 nM. DHFR-IN-26 exerts broad-spectrum antibacterial activity. DHFR-IN-26 disrupts folate metabolism, nucleotide synthesis, and bacterial amino acid metabolic pathways. DHFR-IN-26 disrupts bacterial inner membranes, inhibited biofilm formation, and attenuated phage-related processes. DHFR-IN-26 shows lower toxicity to non-cancerous cells. DHFR-IN-26 can be used for the research of bacterial infections (including infections caused by methicillin-resistant Staphylococcus aureus, multidrug-resistant Escherichia coli, multidrug-resistant Pseudomonas aeruginosa, and lysogenic bacteria) .

HY-175282A

(2S,3R,4S)-ASX-173	Apoptosis Caspase CDK PARP Autophagy	Cancer
(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173 (HY-175282). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC₅₀ = 0.113 μM, K_i = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers .

Cat. No.	Product Name

HY-L227

Amino Acid Metabolite Compound Library	198 compounds
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 198 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Amino Acid Metabolite Compound Library

198 compounds

Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism.

MCE can provide 198 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Fungal
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

Cat. No.	Product Name	Chemical Structure

HY-10250S1

Triciribine phosphate-d3
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

Triciribine phosphate-d3

Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-12784S

Cycloguanil-d6 1 Publications Verification
Cycloguanil-d₆ (Chlorguanide triazine-d₆) is the deuterium labeled Cycloguanil (HY-12784). Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

Cycloguanil-d6

1 Publications Verification

Cycloguanil-d₆ (Chlorguanide triazine-d₆) is the deuterium labeled Cycloguanil (HY-12784). Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784AS

Cycloguanil-d4 hydrochloride
Cycloguanil-d₄ (Chlorguanide triazine-d₄) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

Cycloguanil-d4 hydrochloride

Cycloguanil-d₄ (Chlorguanide triazine-d₄) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784AS1

Cycloguanil-d6 hydrochloride
Cycloguanil-d₆ (Chlorguanide triazine-d₆) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

Cycloguanil-d6 hydrochloride

Cycloguanil-d₆ (Chlorguanide triazine-d₆) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-12784S1

Cycloguanil-d6 nitrate
Cycloguanil-d₆ (Chlorguanide triazine-d₆) nitrate is the deuterium labeled Cycloguanil nitrate. Cycloguanil nitrate is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil nitrate blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil nitrate inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil nitrate also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

Cycloguanil-d6 nitrate

Cycloguanil-d₆ (Chlorguanide triazine-d₆) nitrate is the deuterium labeled Cycloguanil nitrate. Cycloguanil nitrate is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil nitrate blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil nitrate inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil nitrate also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

Cat. No.	Product Name		Classification

HY-N7517

Adenosine 5′-monophosphoramidate sodium		Nucleotide Analogs Adenine Nucleotide
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks