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Cat. No.: HY-138354

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Pyrroline-5-carboxylate

Pyrroline-5-carboxylate is a key intermediate in proline anabolism and catabolism. Pyrroline-5-carboxylate plays important roles in plant defense against pathogen invasion, as well as in redox regulation, nucleotide synthesis and other processes in animal cells.

For research use only. We do not sell to patients.

CAS No.: 2139-03-9
Formula: C₅H₇NO₂
Molecular Weight:113.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Pyrroline-5-carboxylate Chemical Structure

CAS No.: 2139-03-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

Sodium pyrroline-5-carboxylate (0.3-3.0 mM; 1 hour) activates the pentose phosphate pathway in normal human fibroblasts, LLC-RK1 cells and human erythrocytes^[1].
Sodium pyrroline-5-carboxylate (1 μM-0.5 mM; 1 hour) increases the level of phosphoribosyl pyrophosphate in human red blood cells^[1].
Sodium pyrroline-5-carboxylate (0.5 mM; up to 4 hours) increases the level of PP-ribose-P in serum-starved quiescent human fibroblasts in a time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2139-03-9
Molecular Weight 113.11
Formula C₅H₇NO₂
SMILES

O=C(C1=NCCC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. PHANG J M. The regulatory functions of proline and pyrroline-5-carboxylic acid. Current topics in cellular regulation, 1985, 25: 91-132.

[2]. Qamar A, et al. Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens. Front Plant Sci. 2015;6:503. Published 2015 Jul 6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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