Triciribine phosphate
Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity.
For research use only. We do not sell to patients.
- CAS No.: 61966-08-3
- Formula: C13H17N6O7P
- Molecular Weight:400.28
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BSC-1 | IC50 |
20 μM
Compound: TCN-P
|
Antiviral activity was tested using an enzyme-linked immunosorbent assay (ELISA) to detect HSV-1 (herpes simplex virus type 1) using BSC-1 cells
Antiviral activity was tested using an enzyme-linked immunosorbent assay (ELISA) to detect HSV-1 (herpes simplex virus type 1) using BSC-1 cells
|
[PMID: 10882371] |
| BSC-1 | IC50 |
20 μM
Compound: TCN-P
|
Antiviral activity against HSV-1 was determined using BSC-1 cells by an enzyme-linked immunosorbent assay (ELISA)
Antiviral activity against HSV-1 was determined using BSC-1 cells by an enzyme-linked immunosorbent assay (ELISA)
|
[PMID: 10882373] |
| CEM-SS | IC50 |
>1 μM
Compound: TCN-P
|
Tested for visual cytotoxicity on uninfected CEM-SS cells
Tested for visual cytotoxicity on uninfected CEM-SS cells
|
[PMID: 10882371] |
| CEM-SS | IC50 |
>1 μM
Compound: TCN-P
|
Visual cytotoxicity was scored on CEM-SS cells
Visual cytotoxicity was scored on CEM-SS cells
|
[PMID: 10882373] |
| HFF | IC50 |
0.8 μM
Compound: TCN-P
|
HCMV plaque assay was performed using HFF cells and effect was calculated as a percentage of reduction in number of plaques
HCMV plaque assay was performed using HFF cells and effect was calculated as a percentage of reduction in number of plaques
|
[PMID: 10882371] |
| HFF | IC50 |
0.8 μM
Compound: TCN-P
|
Antiviral activity against HCMV was determined by plaque reduction assay using HFF cells
Antiviral activity against HCMV was determined by plaque reduction assay using HFF cells
|
[PMID: 10882373] |
| HFF | IC50 |
19 μM
Compound: TCN-P
|
Tested for visual cytotoxicity on uninfected HFF cells
Tested for visual cytotoxicity on uninfected HFF cells
|
[PMID: 10882371] |
| HFF | IC50 |
19 μM
Compound: TCN-P
|
Visual cytotoxicity was scored on uninfected HFF cells
Visual cytotoxicity was scored on uninfected HFF cells
|
[PMID: 10882373] |
| KB | IC50 |
10 μM
Compound: TCN-P
|
Inhibition of KB cell growth was assessed
Inhibition of KB cell growth was assessed
|
[PMID: 10882371] |
| KB | IC50 |
10 μM
Compound: TCN-P
|
Cytotoxicity measured as Inhibition of KB cell growth was assessed.
Cytotoxicity measured as Inhibition of KB cell growth was assessed.
|
[PMID: 10882373] |
| L1210 | IC50 |
0.025 μM
Compound: TCN-P
|
Tested in vitro for cytotoxicity against murine L1210 leukemic cells
Tested in vitro for cytotoxicity against murine L1210 leukemic cells
|
[PMID: 10882371] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 61966-08-3
-
Appearance Solid
-
Molecular Weight 400.28
-
Formula C13H17N6O7P
-
Color Light yellow to yellow
-
SMILES
NC1=NN(C)C2=C3C1=CN([C@@H]4O[C@@H]([C@H]([C@H]4O)O)COP(O)(O)=O)C3=NC=N2
-
Synonyms
TCN-P
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Triciribine phosphate Related Classifications
HY-10250 Related Classifications
Powered by Bioz