61966-08-3
Chemical Structure
Triciribine phosphate
Synonym(s): TCN-P
- CAS No.: 61966-08-3
- Formula:C13H17N6O7P
- Molecular Weight:400.28
IUPAC Name: ((2R,3S,4R)-5-(3-amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: URLYINUFLXOMHP-HTVVRFAVSA-N
SMILES: NC1=NN(C)C2=C3C1=CN([C@@H]4O[C@@H]([C@H]([C@H]4O)O)COP(O)(O)=O)C3=NC=N2
Biological Activity: Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].
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Triciribine phosphate | Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity. | |||||||||||||||||||||
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Triciribine phosphate-13C,d3 | Triciribine phosphate--13C,d3 is the deuterium and 13C labeled Triciribine phosphate. | |||||||||||||||||||||
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