Mafenide hydrochloride
Based on 1 Customer Validation
Mafenide hydrochloride is a potent sulfonamide antimicrobial agent. Mafenide hydrochloride exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide hydrochloride also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide hydrochloride can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 138-37-4
- Formula: C7H11ClN2O2S
- Molecular Weight:222.70
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Mafenide hydrochloride (5%) maintains antimicrobial activity with a zone of inhibition >2 mm against Staphylococcus aureus and Pseudomonas aeruginosa in vitro[1].
Mafenide hydrochloride (2.5%-7.5%; 1-24 h) exhibits dose-dependent antifungal activity against filamentous fungi (e.g., Lichtheimia spp., Aspergillus flavus)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human keratinocytes (HEK-001; ATCC CRL-2404), human dermal fibroblasts (PromoCell), human osteoblasts (PromoCell)
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Concentration:2.5%, 5%, 7.5%
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Incubation Time:0.5 h, 1 h, 3 h, 24 h
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Result:Showed a viability range of 30%-78% (fibroblasts).
Showed a viability range of 31%-77% (keratinocytes).
Showed a viability range of 22%-81% (osteoblasts).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar albino rats (mean weight 200 g) with Pseudomonas aeruginosa-contaminated full-thickness skin graft (FTSG) model (2.5×2.5 cm FTSG harvested from back, wound bed inoculated with 107 CFU/mL Pseudomonas aeruginosa in 0.6 mL buffer solution)[4]
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Dosage:2.5% Mafenide Acetate solution
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Administration:Topical application via soaked dressings (hydrofiber or gauze); group 3 (hydrofiber + MA): dressing changed every 2 days; group 4 (gauze + MA): dressing changed twice a day; total cycle of 14 days
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Result:Showed a mean graft survival rate of 50.1% in group 3 and 66.3% in group 4.
Showed detachment of the dermal-epidermal junction, collagen disorganization, decreased fibroblast number, and decreased capillary count.
Chemical Information
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CAS No. 138-37-4
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Appearance Solid
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Molecular Weight 222.70
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Formula C7H11ClN2O2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(CN)C=C1)(N)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (561.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Ashkan Afshari, et al. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39(5):736-738. [Content Brief]
[2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324. [Content Brief]
[3]. Barsoumian A, et al. In vitro toxicity and activity of Dakin's solution, mafenide acetate, and amphotericin B on filamentous fungi and human cells. J Orthop Trauma. 2013 Aug;27(8):428-36. [Content Brief]
[4]. Baver Acaban M, et al. The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds. Burns. 2024 Mar;50(2):433-443. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4903 mL | 22.4517 mL | 44.9035 mL | 112.2586 mL |
| 5 mM | 0.8981 mL | 4.4903 mL | 8.9807 mL | 22.4517 mL | |
| 10 mM | 0.4490 mL | 2.2452 mL | 4.4903 mL | 11.2259 mL | |
| 15 mM | 0.2994 mL | 1.4968 mL | 2.9936 mL | 7.4839 mL | |
| 20 mM | 0.2245 mL | 1.1226 mL | 2.2452 mL | 5.6129 mL | |
| 25 mM | 0.1796 mL | 0.8981 mL | 1.7961 mL | 4.4903 mL | |
| 30 mM | 0.1497 mL | 0.7484 mL | 1.4968 mL | 3.7420 mL | |
| 40 mM | 0.1123 mL | 0.5613 mL | 1.1226 mL | 2.8065 mL | |
| 50 mM | 0.0898 mL | 0.4490 mL | 0.8981 mL | 2.2452 mL | |
| 60 mM | 0.0748 mL | 0.3742 mL | 0.7484 mL | 1.8710 mL | |
| 80 mM | 0.0561 mL | 0.2806 mL | 0.5613 mL | 1.4032 mL | |
| 100 mM | 0.0449 mL | 0.2245 mL | 0.4490 mL | 1.1226 mL |
Mafenide hydrochloride Related Classifications
HY-B0614B Related Classifications
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