Sulisobenzone
Based on 1 publication(s) in Google Scholar
Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 4065-45-6
- Formula: C14H12O6S
- Molecular Weight:308.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sulisobenzone
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Biological Activity
Sulisobenzone (3.1-98.7 mg/L) downregulates thyroid hormone-regulated genes in rat pituitary cell lines[1].
Sulisobenzone (76 mg/L) induces oxidative damage and reduces viability in the microalga Chlamydomonas reinhardtii, increasing ROS levels by up to 1.5-fold and decreasing growth rate, membrane potentials, metabolic activity, and autofluorescence[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Juvenile gilt-head sea bream[1]
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Dosage:10 μg/L
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Administration:waterborne; 22 days
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Result:Detected 371 differentially expressed genes in liver, with 48 down-regulated and 323 up-regulated.
Identified 123 differentially modulated features in plasma and 118 in liver.
Increased thyroid hormone receptor beta (FC = 2.4), retinol-binding protein (FC = 2.78), cytochrome P450 isoforms (FC = 2.21 and 2.56), and aryl hydrocarbon receptor nuclear translocator-like protein 1 (FC = 2.43) in liver.
Increased L-arginine (97.1% change), phosphocreatine (31.9% change), and 2'-deoxyguanosine (50.0% change) in plasma.
Decreased L-phenylalanine (97.3% change), L-tyrosine (164.2% change), and guanosine (128.4% change), and increased 3,4-dihydroxyhydrocinnamic acid (63.7% change) and L-acetylcarnitine (68.5% change) in liver.
Chemical Information
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CAS No. 4065-45-6
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Appearance Solid
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Molecular Weight 308.31
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Formula C14H12O6S
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Color White to off-white
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SMILES
O=S(C1=CC(C(C2=CC=CC=C2)=O)=C(O)C=C1OC)(O)=O
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Synonyms
Benzophenone-4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543
Solvent & Solubility
H2O : ≥ 100 mg/mL (324.35 mM)
DMSO : ≥ 34 mg/mL (110.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 3.2435 mL | 16.2174 mL | 32.4349 mL | 81.0872 mL |
| 5 mM | 0.6487 mL | 3.2435 mL | 6.4870 mL | 16.2174 mL | |
| 10 mM | 0.3243 mL | 1.6217 mL | 3.2435 mL | 8.1087 mL | |
| 15 mM | 0.2162 mL | 1.0812 mL | 2.1623 mL | 5.4058 mL | |
| 20 mM | 0.1622 mL | 0.8109 mL | 1.6217 mL | 4.0544 mL | |
| 25 mM | 0.1297 mL | 0.6487 mL | 1.2974 mL | 3.2435 mL | |
| 30 mM | 0.1081 mL | 0.5406 mL | 1.0812 mL | 2.7029 mL | |
| 40 mM | 0.0811 mL | 0.4054 mL | 0.8109 mL | 2.0272 mL | |
| 50 mM | 0.0649 mL | 0.3243 mL | 0.6487 mL | 1.6217 mL | |
| 60 mM | 0.0541 mL | 0.2703 mL | 0.5406 mL | 1.3515 mL | |
| 80 mM | 0.0405 mL | 0.2027 mL | 0.4054 mL | 1.0136 mL | |
| 100 mM | 0.0324 mL | 0.1622 mL | 0.3243 mL | 0.8109 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sulisobenzone Related Classifications
HY-B1162 Related Classifications
Powered by Bioz
- Sulisobenzone
- 4065-45-6
- Benzophenone-4
- Benzophenone4
- Benzophenone 4
- Environmental Pollutants
- Biochemical Assay Reagents
- gilt-head sea bream plasma
- oxidative stress
- carbohydrate metabolic pathways
- steroid hormone biosynthesis pathways
- gilt-head sea bream liver
- rat pituitary cell lines
- Chlamydomonas reinhardtii
- amino acid metabolic pathways
- thyroid hormone biosynthesis pathways
- energy metabolism
- Inhibitor
- inhibitor
- inhibit