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Results for "

pyrimidine metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminotransferases (Transaminases) (4) Antibiotic (1) Apoptosis (1) Bacterial (1) Caspase (1) DNA/RNA Synthesis (3) Drug Metabolite (1) Endogenous Metabolite (21) Ferroptosis (1) Fungal (1) Interleukin Related (1) Isotope-Labeled Compounds (8) Keap1-Nrf2 (1) Mitophagy (1) MMP (1) Notch (1) Nucleoside Antimetabolite/Analog (13) Parasite (1) Phosphorylase (1) PINK1/Parkin (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Thymidylate Synthase (4)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Infection (6) Inflammation/Immunology (1) Metabolic Disease (6) Neurological Disease (14)
Oligonucleotides:	Nucleotide Analogs (1) Nucleoside Analogs (2) Cytidine (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0158

Cytidine 5+ Cited Publications Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Endogenous Metabolite	Others
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-D0186

2'-Deoxyuridine 3 Publications Verification	Endogenous Metabolite Thymidylate Synthase	Infection
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-P3016A

Aspartate aminotransferase, porcine heart EC 2.6.1.1, porcine heart; GOT, porcine heart; AST, porcine heart	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), porcine heart is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, porcine heart comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, porcine heart also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, porcine heart is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-148165

L-Cytidine	Nucleoside Antimetabolite/Analog	Neurological Disease
L-Cytidine is an L-configurational form of Cytidine (HY-B0158). L-Cytidine is a pyrimidine nucleoside, a component of RNA. Cytidine can control the glial glutamate cycle, affect brain phospholipid metabolism, catecholamine synthesis and mitochondrial function .

HY-P3016

Aspartate aminotransferase, Genetically engineered bacteria EC 2.6.1.1; GOT; AST	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Genetically engineered bacteria is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Genetically engineered bacteria comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Genetically engineered bacteria also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Genetically engineered bacteria is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-B0158S7

Cytidine-13C9 Cytosine β-D-riboside-¹³C₉; Cytosine-1-β-D-ribofuranoside-¹³C₉	Nucleoside Antimetabolite/Analog Endogenous Metabolite Isotope-Labeled Compounds	Neurological Disease
Cytidine- ¹³C₉ (Cytosine β-D-riboside- ¹³C₉) is ¹³C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B0158S6

Cytidine-15N3 Cytosine β-D-riboside-¹⁵N₃; Cytosine-1-β-D-ribofuranoside-¹⁵N₃	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine- ¹⁵N₃ is the ¹⁵N labeled Cytidine . Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B0158R

Cytidine (Standard) Cytosine β-D-riboside (Standard); Cytosine-1-β-D-ribofuranoside (Standard)	Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine (Standard) is the analytical standard of Cytidine. This product is intended for research and analytical applications. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function . In Vivo:Cytidine decreases glutamate/glutamine levels and induces earlier improvement of depressive symptoms .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Fungal	Infection
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-164826

Acetyl zingerone	Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis	Inflammation/Immunology Cancer
Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3 inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and PINK1/Parkin-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .

HY-B0158S1

Cytidine-13C Cytosine β-D-riboside-¹³C; Cytosine-1-β-D-ribofuranoside-¹³C	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog	Neurological Disease
Cytidine- ¹³C is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine

HY-B0158S

Cytidine-d2 Cytosine β-D-riboside-d₂; Cytosine-1-β-D-ribofuranoside-d₂	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine-d₂ is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-P3016B

Aspartate aminotransferase, Human liver EC 2.6.1.1, Human liver; GOT, Human liver; AST, Human liver	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Human liver is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human liver comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human liver also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human liver is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-D0186R

2'-Deoxyuridine (Standard)	Reference Standards Endogenous Metabolite Thymidylate Synthase	Infection
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Endogenous Metabolite	Others
D-Ribofuranose 1-dihydrogenphosphate (Ribose 1-phosphate) dicyclohexanamine is a pentose phosphate and serves as a key intermediate metabolite in the salvage synthesis pathway of purine and pyrimidine nucleotides. In nucleotide salvage synthesis, D-Ribofuranose 1-dihydrogenphosphate dicyclohexanamine directly "transfers" the ribosyl group from purine nucleosides to pyrimidine bases, acting as a hub molecule linking nucleoside/base metabolism with pentose phosphate metabolism .

HY-B0158S2

Cytidine-13C-1 Cytosine β-D-riboside-¹³C-1; Cytosine-1-β-D-ribofuranoside-¹³C-1	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog	Neurological Disease
Cytidine- ¹³C-1 is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami

HY-B0158S5

Cytidine-13C9,15N3 Cytosine β-D-riboside-¹³C₉,¹⁵N₃; Cytosine-1-β-D-ribofuranoside-¹³C₉,¹⁵N₃	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine- ¹³C₉, ¹⁵N₃ is the ¹³C and ¹⁵N labeled Cytidine . Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W768207

Cytidine-1',2',3',4',5'-13C5	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Endogenous Metabolite	Neurological Disease
Cytidine-1',2',3',4',5'- ¹³C₅ is the ¹³C-labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W778990

2-Deoxyuridine-1,2,3,4,5-13C5	Isotope-Labeled Compounds Thymidylate Synthase Endogenous Metabolite	Infection
2-Deoxyuridine-1,2,3,4,5- ¹³C₅ is the ¹³C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-N14611

Pyrazomycin Ⅱ Pyrazomycin B	Antibiotic Bacterial	Infection
Pyrazomycin II (Pyrazomycin B) is an antibiotic. Pyrazomycin is a competitive inhibitor of pyrimidine nucleoside metabolism .

HY-W158234

N-Methylbenzo[d]oxazol-2-amine	Parasite	Infection
N-Methylbenzo[d]oxazol-2-amine (compound 1) is an anthelmintic activity and lower cytotoxicity against T. spiralis adult worm. N-Methylbenzo[d]oxazol-2-amine up-regulates the metabolism of purine, pyrimidine and down-regulates sphingolipid metabolism .

HY-B0158S4

Cytidine-d1 Cytosine β-D-riboside-d₁; Cytosine-1-β-D-ribofuranoside-d₁	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog	Neurological Disease
Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol

HY-B0158S3

Cytidine-d2-1 Cytosine β-D-riboside-d₂-1; Cytosine-1-β-D-ribofuranoside-d₂-1	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog	Neurological Disease
Cytidine-d₂-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech

HY-N0157C

Orotic acid potassium 3 Publications Verification 6-Carboxyuracil potassium; Vitamin B13 potassium	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats .

HY-B0158S8

Cytidine-d13 Cytosine β-D-riboside-d₁₃; Cytosine-1-β-D-ribofuranoside-d₁₃	Nucleoside Antimetabolite/Analog Endogenous Metabolite Isotope-Labeled Compounds	Neurological Disease
Cytidine-d₁₃ (Cytosine β-D-riboside-d₁₃) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-P2916

Thymidine phosphorylase	Phosphorylase	Cardiovascular Disease Neurological Disease Cancer
Thymidine phosphorylase is a nucleoside metabolism enzyme that plays an important role in the pyrimidine salvage pathway. Thymidine phosphorylase catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Thymidine phosphorylase plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Thymidine phosphorylase can be used for the study of myocardial infarction, stroke, pulmonary embolism and cancer .

HY-128738R

Thymidine-5'-monophosphate disodium salt (Standard) TMP disodium salt (Standard)	Reference Standards Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.

HY-P3241A

Nucleoside Phosphorylase, bacterial	Endogenous Metabolite	Metabolic Disease
Nucleoside Phosphorylase, bacterial (EC 2.4.2.1), is a pentosesyltransferase. Nucleoside Phosphorylase participates in three metabolic pathways: purine metabolism, pyrimidine metabolism, and nicotinic acid and nicotinamide metabolism. Its two substrates are purine nucleosides and phosphates, and its two products are purines and α-D-ribose-1-phosphate.

HY-W720429

2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine	Drug Metabolite	Metabolic Disease
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the biosynthesis pathway (purine metabolism process) of Riboflavin (HY-B0456) .

HY-E70912

Prokaryotic Thymidylate kinase	Thymidylate Synthase	Metabolic Disease
Prokaryotic thymidylate kinase (EC 2.7.4.9) is an enzyme that transfers phosphorus-containing groups (phosphotransferases) using phosphate groups as acceptors. Prokaryotic thymidylate kinase participates in pyrimidine metabolism. Its two substrates are ATP and dTMP, and its two products are ADP and dTDP.

HY-P3016C

Aspartate aminotransferase, Human (HEK293) EC 2.6.1.1, Human (HEK293); GOT, Human (HEK293); AST, Human (HEK293)	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Human (HEK293) is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human (HEK293) comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human (HEK293) also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human (HEK293) is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library	572 compounds
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications. MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-N0157C

Orotic acid potassium 3 Publications Verification 6-Carboxyuracil potassium; Vitamin B13 potassium	Biochemical Assay Reagents
Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats .

Orotic acid potassium

3 Publications Verification

6-Carboxyuracil potassium; Vitamin B13 potassium

Biochemical Assay Reagents

Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0158

Cytidine 5+ Cited Publications Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside	Natural Products Human Gut Microbiota Metabolites Microorganisms other families Animals Disease markers Nervous System Disorder Plants Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-D0186

2'-Deoxyuridine 3 Publications Verification	Infection Natural Products Immune System Disorder Microorganisms Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Thymidylate Synthase
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-B0158R

Cytidine (Standard) Cytosine β-D-riboside (Standard); Cytosine-1-β-D-ribofuranoside (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms other families Animals Disease markers Nervous System Disorder Plants Endogenous metabolite Source Classification	Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine (Standard) is the analytical standard of Cytidine. This product is intended for research and analytical applications. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function . In Vivo:Cytidine decreases glutamate/glutamine levels and induces earlier improvement of depressive symptoms .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Fungal
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-D0186R

2'-Deoxyuridine (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Thymidylate Synthase
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Ribofuranose 1-dihydrogenphosphate (Ribose 1-phosphate) dicyclohexanamine is a pentose phosphate and serves as a key intermediate metabolite in the salvage synthesis pathway of purine and pyrimidine nucleotides. In nucleotide salvage synthesis, D-Ribofuranose 1-dihydrogenphosphate dicyclohexanamine directly "transfers" the ribosyl group from purine nucleosides to pyrimidine bases, acting as a hub molecule linking nucleoside/base metabolism with pentose phosphate metabolism .

HY-N14611

Pyrazomycin Ⅱ Pyrazomycin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Pyrazomycin II (Pyrazomycin B) is an antibiotic. Pyrazomycin is a competitive inhibitor of pyrimidine nucleoside metabolism .

HY-128738R

Thymidine-5'-monophosphate disodium salt (Standard) TMP disodium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Endogenous Metabolite DNA/RNA Synthesis
Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.

Cat. No.	Product Name	Chemical Structure

HY-B0158S7

Cytidine-13C9
Cytidine- ¹³C₉ (Cytosine β-D-riboside- ¹³C₉) is ¹³C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B0158S6

Cytidine-15N3
Cytidine- ¹⁵N₃ is the ¹⁵N labeled Cytidine . Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B0158S1

Cytidine-13C
Cytidine- ¹³C is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine

HY-B0158S

Cytidine-d2
Cytidine-d₂ is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B0158S2

Cytidine-13C-1
Cytidine- ¹³C-1 is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami

HY-B0158S5

Cytidine-13C9,15N3
Cytidine- ¹³C₉, ¹⁵N₃ is the ¹³C and ¹⁵N labeled Cytidine . Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W768207

Cytidine-1',2',3',4',5'-13C5
Cytidine-1',2',3',4',5'- ¹³C₅ is the ¹³C-labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-W778990

2-Deoxyuridine-1,2,3,4,5-13C5

2-Deoxyuridine-1,2,3,4,5- ¹³C₅ is the ¹³C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-B0158S4

Cytidine-d1
Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol

HY-B0158S3

Cytidine-d2-1
Cytidine-d₂-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech

HY-B0158S8

Cytidine-d13
Cytidine-d₁₃ (Cytosine β-D-riboside-d₁₃) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

Cat. No.	Product Name		Classification

HY-B0158

Cytidine 5+ Cited Publications Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside		Nucleoside Analogs Cytidine
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt		Nucleotide Analogs
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-148165

L-Cytidine		Nucleoside Analogs Cytidine
L-Cytidine is an L-configurational form of Cytidine (HY-B0158). L-Cytidine is a pyrimidine nucleoside, a component of RNA. Cytidine can control the glial glutamate cycle, affect brain phospholipid metabolism, catecholamine synthesis and mitochondrial function .

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