Cytidine-13C-1
Based on 1 Customer Validation
Cytidine-13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
For research use only. We do not sell to patients.
- Purity : 99.37%
- CAS No.: 478511-19-2
- Formula: C813CH13N3O5
- Molecular Weight:244.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 478511-19-2
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Unlabeled CAS 65-46-3
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Appearance Solid
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Molecular Weight 244.21
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Formula C813CH13N3O5
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SMILES
OC[C@@H]1[C@@H](O)[13C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1
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Synonyms
Cytosine β-D-riboside-13C-1; Cytosine-1-β-D-ribofuranoside-13C-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (204.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. 2001;45(6):235-54.;Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000 Oct 1;60(7):989-92.;Machado-Vieira R, et, al. N [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.0948 mL | 20.4742 mL | 40.9484 mL | 102.3709 mL |
| 5 mM | 0.8190 mL | 4.0948 mL | 8.1897 mL | 20.4742 mL | |
| 10 mM | 0.4095 mL | 2.0474 mL | 4.0948 mL | 10.2371 mL | |
| 15 mM | 0.2730 mL | 1.3649 mL | 2.7299 mL | 6.8247 mL | |
| 20 mM | 0.2047 mL | 1.0237 mL | 2.0474 mL | 5.1185 mL | |
| 25 mM | 0.1638 mL | 0.8190 mL | 1.6379 mL | 4.0948 mL | |
| 30 mM | 0.1365 mL | 0.6825 mL | 1.3649 mL | 3.4124 mL | |
| 40 mM | 0.1024 mL | 0.5119 mL | 1.0237 mL | 2.5593 mL | |
| 50 mM | 0.0819 mL | 0.4095 mL | 0.8190 mL | 2.0474 mL | |
| 60 mM | 0.0682 mL | 0.3412 mL | 0.6825 mL | 1.7062 mL | |
| 80 mM | 0.0512 mL | 0.2559 mL | 0.5119 mL | 1.2796 mL | |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4095 mL | 1.0237 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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