Search Result
Results for "
thioether
" in MedChemExpress (MCE) Product Catalog:
47
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-W009749
-
|
|
Endogenous Metabolite
Apoptosis
|
Cardiovascular Disease
|
|
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection .
|
-
-
- HY-166648
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .
|
-
-
- HY-P10375
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987 .
|
-
-
- HY-172320
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMS-986238 is an orally active macrocyclic peptide PD-L1 inhibitor. BMS-986238 can be used in the research of tumors such as solid tumors and lymphomas .
|
-
-
- HY-P3440
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PD-1/PD-L1
|
Cancer
|
|
WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression .
|
-
-
- HY-W440719
-
|
|
Liposome
|
Cancer
|
|
Cholesterol-PEG2000-MAL is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.
|
-
-
- HY-E70277
-
|
|
ATGL
|
Metabolic Disease
|
|
Hexadecyl-CoA is a thioether analog of acyl-CoA that can inhibit adipose triglyceride lipase (ATGL) .
|
-
-
- HY-P10950A
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide TFA binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide TFA is promising for research of cancers .
|
-
-
- HY-174921A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimide-PEG2000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
-
- HY-166648A
-
|
|
Liposome
|
Others
|
|
DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .
|
-
-
- HY-130082
-
|
|
ADC Payload
Microtubule/Tubulin
|
Cancer
|
|
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe is a highly toxic metabolite that can be oxidized and detoxified by human liver microsomes .
|
-
-
- HY-P5963
-
-
-
- HY-W009749C
-
|
|
Endogenous Metabolite
Apoptosis
|
Cardiovascular Disease
|
|
L-Cystathionine (dihydrochloride) is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine (dihydrochloride) protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine (dihydrochloride) plays an important role in cardiovascular protection .
|
-
-
- HY-P99685
-
|
IMGN-289; J2898A-SMCC-DM1
|
EGFR
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
|
Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research .
|
-
-
- HY-W012166
-
|
NHS-Bromoacetate
|
Biochemical Assay Reagents
|
Infection
|
|
N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .
|
-
-
- HY-W591393
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Biotin Azide Plus is an oxazolidine reagent that integrates azide-biotin click chemistry and a photocleavable linker arm. Biotin Azide Plus not only reacts with biotin thioether to form stable sulfinimide products, but also enables bioconjugation of proteins and DNA through biotin redox-activated chemical labeling technology. Taking advantage of the streptavidin capture and photo-release properties, Biotin Azide Plus effectively facilitates the isolation of lipid-derived electrophile-protein adducts, thus finding wide application in scientific research related to fields such as SKBR3 cancer .
|
-
-
- HY-P10950
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .
|
-
-
- HY-N16290
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chol-PEG2000-maleimide is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
-
- HY-W440995
-
|
|
Liposome
|
Cancer
|
|
DOPE-PEG2000-Mal is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
|
-
-
- HY-D2529
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG2000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
-
- HY-P5984
-
|
|
mTOR
|
Others
|
|
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
|
-
-
- HY-P10714
-
|
|
Proteasome
Apoptosis
Deubiquitinase
|
Cancer
|
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM .
|
-
-
- HY-174953A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPP-PEG2000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
-
- HY-174953B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPP-PEG3400-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
-
- HY-D2497
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
-
- HY-D2531
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG5000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
-
- HY-D2556
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5.5-PEG1000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
-
- HY-W879049
-
|
DBCO-NHCO-PEG3-maleimide
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG3-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
-
- HY-P5984A
-
|
|
mTOR
|
Others
|
|
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
|
-
-
- HY-161096
-
|
|
ROR
|
Cancer
|
|
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines .
|
-
-
- HY-126781
-
|
BM-211290
|
HIV
DNA/RNA Synthesis
|
Infection
|
|
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
-
- HY-W440718C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cholesterol-PEG10000-Mal is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
-
- HY-174953
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPP-PEG1000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
-
- HY-W588728
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG8-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
-
- HY-167036C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DMG-PEG5000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG5000-Mal can be used for drug delivery .
|
-
-
- HY-130081
-
|
|
ADC Payload
Microtubule/Tubulin
|
Cancer
|
|
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM .
|
-
-
- HY-W591465
-
|
4-Arm-PEG2000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG2000-Maleimide (4-Arm-PEG2000-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
-
- HY-D2532
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG10000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
-
- HY-D2589
-
|
|
Fluorescent Dye
|
Others
|
|
Cy7.5 PEG-SH is a fluorescent labeling reagent that combines CY7.5 (HY-D0926) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em = 770/820 nm).
|
-
-
- HY-W879036
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG8-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG8-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
-
- HY-174927E
-
|
DBCO-PEG3400-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG3400-Maleimide (DBCO-PEG3400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
-
- HY-174927B
-
|
DBCO-PEG600-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG600-Maleimide (DBCO-PEG600-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG600-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
-
- HY-174927A
-
|
DBCO-PEG400-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG400-Maleimide (DBCO-PEG400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
-
- HY-174927D
-
|
DBCO-PEG2000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG2000-Maleimide (DBCO-PEG2000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG2000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
-
- HY-174927H
-
|
DBCO-PEG10000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG10000-Maleimide (DBCO-PEG10000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG10000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
-
- HY-P11316
-
|
|
Biochemical Assay Reagents
Drug-Linker Conjugates for ADC
|
Others
|
|
DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907)) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research .
|
-
-
- HY-149275
-
|
|
Pyruvate Kinase
PDK-1
Akt
EGFR
Apoptosis
|
Cancer
|
|
PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis. PKM2/PDK1-IN-1 induces intercellular ROS production, and regulates the apoptotic proteins, to involves in mitochondrial and death receptor pathway .
|
-
-
- HY-P2331
-
|
Antibiotic A 3802-IV-3; Gardimycin
|
Antibiotic
|
Infection
|
|
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
|
-
-
- HY-129846
-
|
|
Biochemical Assay Reagents
|
Others
|
|
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific
reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .
|
-
-
- HY-N16237
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chol-PEG1000-maleimide is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-W440722
-
|
|
Liposome
|
Others
|
|
Cholesterol-PEG1000-Thiol is a PEGylated lipid that forms micelles in water and can be used to prepare liposomes or nanoparticles as drug delivery systems. The thiol moiety reacts with maleimide to form a stable thioether bond .
|
-
- HY-CE01263
-
-
- HY-W440724
-
|
|
Liposome
|
Cancer
|
|
Cholesterol-PEG3400-Thiol is an amphiphatic PEG derivative which forms micelles in water and can be used to prepare liposomes or nanoparticles for drug delivery system. The thiol moiety is reactive with maleimide to form a stable thioether bond.
|
-
- HY-W009749R
-
|
|
Reference Standards
Endogenous Metabolite
Apoptosis
|
Cardiovascular Disease
|
|
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection .
|
-
- HY-W588736
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG23-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
- HY-174921B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimide-PEG3400-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimide-PEG5000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimide-PEG1000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-W441003
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG2000-IA is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine.
|
-
- HY-167036A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DMG-PEG1000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG1000-Mal can be used for drug delivery .
|
-
- HY-W591618D
-
|
4-Arm-PEG3400-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG3400-Maleimide (4-Arm-PEG3400-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W591618A
-
|
4-Arm-PEG400-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG400-Maleimide (4-Arm-PEG400-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W591618C
-
|
4-Arm-PEG1000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG1000-Maleimide (4-Arm-PEG1000-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W440902
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG3400-IA is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage.
|
-
- HY-D2883E
-
|
Rhodamine B-PEG5000-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG5000-SH (Rhodamine B-PEG5000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883D
-
|
Rhodamine B-PEG3400-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG3400-SH (Rhodamine B-PEG3400-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2509
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG1000-SH is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2883
-
|
Rhodamine B-PEG400-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG400-SH (Rhodamine B-PEG400-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-174927
-
|
DBCO-PEG5000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG5000-Maleimide (DBCO-PEG5000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG5000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927C
-
|
DBCO-PEG1000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG1000-Maleimide (DBCO-PEG1000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG1000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-W800679
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-Cyclohexyl-PEG3-Biotin is a PEG linker containing a maleimide moiety and a biotin group. Maleimides react specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The biotinylation can react with amine molecules in the presence of activator EDC or HATU. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein. The PEG moiety also increases solubility of Biotin-PEG conjugates considerably.
|
-
- HY-174961C
-
|
Fmoc-NH-PEG5000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-PEG5000-Maleimide (Fmoc-NH-PEG5000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174961
-
|
Fmoc-NH-PEG1000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-PEG1000-Maleimide (Fmoc-NH-PEG1000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W394935
-
|
Disulfide,bis(2,4-dimethylphenyl)
|
Biochemical Assay Reagents
|
Others
|
|
Dixylyl disulphide (Disulfide, bis(2,4-dimethylphenyl)) is a 1,2-bis(2,4-dimethylphenyl) thioether that can serve as an impurity reference standard for hydrobromide vortioxetine, used for monitoring impurities in the synthesis process. Hydrobromide vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist and a 5-HT1A receptor agonist, exhibiting antidepressant activity .
|
-
- HY-174953D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPP-PEG10000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-174953C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPP-PEG5000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-W440727
-
|
|
Liposome
|
Cancer
|
|
Cholesterol-PEG2000-Vinylsulfone is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
|
-
- HY-174809A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG600-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG5000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG10000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG400-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG2000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG3400-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Arm-PEG1000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-167036D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DMG-PEG10000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG10000-Mal can be used for drug delivery .
|
-
- HY-167036B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DMG-PEG3400-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG3400-Mal can be used for drug delivery .
|
-
- HY-D2530
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3400-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-W591618B
-
|
4-Arm-PEG600-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG600-Maleimide (4-Arm-PEG600-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-D2883B
-
|
Rhodamine B-PEG1000-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG1000-SH (Rhodamine B-PEG1000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883C
-
|
Rhodamine B-PEG2000-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG2000-SH (Rhodamine B-PEG2000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883H
-
|
Rhodamine B-PEG10000-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG10000-SH (Rhodamine B-PEG10000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883A
-
|
Rhodamine B-PEG600-SH
|
Fluorescent Dye
|
Others
|
|
RB-PEG600-SH (Rhodamine B-PEG600-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2512
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG5000-SH is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2557
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5.5-PEG3400-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2559
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5.5-PEG10000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2558
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5.5-PEG5000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-W009749CR
-
|
|
Reference Standards
Endogenous Metabolite
Apoptosis
|
Cardiovascular Disease
|
|
L-Cystathionine dihydrochloride (Standard) is the analytical standard of L-Cystathionine dihydrochloride (HY-W009749C). This product is intended for research and analytical applications. L-Cystathionine dihydrochloride is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine dihydrochloride protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine dihydrochloride plays an important role in cardiovascular protection.
|
-
- HY-D2925
-
|
dTCO-SNAP
|
Biochemical Assay Reagents
|
Others
|
|
dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .
|
-
- HY-174961B
-
|
Fmoc-NH-PEG3400-Mal
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-PEG3400-Maleimide (Fmoc-NH-PEG3400-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174961A
-
|
Fmoc-NH-PEG2000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-PEG2000-Maleimide (Fmoc-NH-PEG2000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-P11673
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Zabopegdutide is a glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist. Zabopegdutide can be used for the study of obesity .
|
-
- HY-D2956
-
|
CLIP-GLA-NHS
|
Biochemical Assay Reagents
|
Others
|
|
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .
|
-
- HY-150087
-
|
|
Fluorescent Dye
|
Others
|
|
Ctrl-CF4-S2 is a chemically modified control probe of the copper probe Copper Fluor-4 (CF4, HY-150086), in which two of the four thioether ligands in CF4 (HY-150086) are replaced with methylene groups. CF4 (HY-150086) is a fluorescent probe used for detecting the presence and distribution of copper ions, whereas Ctrl-CF4-S2 does not respond to copper ions. This allows it to eliminate background signals from copper, thereby helping to determine whether the signals from CF4 (HY-150086) accurately reflect the dynamic changes of copper ions in biological systems
|
-
- HY-D2763
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
|
-
- HY-W068119A
-
|
2-Maleimidoethylamine hydrochloride
|
Biochemical Assay Reagents
|
Cancer
|
|
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .
|
-
- HY-W020780
-
|
mPEG5000-Maleimide
|
Biochemical Assay Reagents
|
Cancer
|
|
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W591393
-
|
|
Fluorescent Dye
|
|
Biotin Azide Plus is an oxazolidine reagent that integrates azide-biotin click chemistry and a photocleavable linker arm. Biotin Azide Plus not only reacts with biotin thioether to form stable sulfinimide products, but also enables bioconjugation of proteins and DNA through biotin redox-activated chemical labeling technology. Taking advantage of the streptavidin capture and photo-release properties, Biotin Azide Plus effectively facilitates the isolation of lipid-derived electrophile-protein adducts, thus finding wide application in scientific research related to fields such as SKBR3 cancer .
|
-
- HY-D2529
-
|
|
Fluorescent Dye
|
|
Cy5-PEG2000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-150087
-
|
|
Fluorescent Dye
|
|
Ctrl-CF4-S2 is a chemically modified control probe of the copper probe Copper Fluor-4 (CF4, HY-150086), in which two of the four thioether ligands in CF4 (HY-150086) are replaced with methylene groups. CF4 (HY-150086) is a fluorescent probe used for detecting the presence and distribution of copper ions, whereas Ctrl-CF4-S2 does not respond to copper ions. This allows it to eliminate background signals from copper, thereby helping to determine whether the signals from CF4 (HY-150086) accurately reflect the dynamic changes of copper ions in biological systems
|
-
- HY-D2497
-
|
|
Fluorescent Dye
|
|
Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2531
-
|
|
Fluorescent Dye
|
|
Cy5-PEG5000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2556
-
|
|
Fluorescent Dye
|
|
Cy5.5-PEG1000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2956
-
|
CLIP-GLA-NHS
|
Fluorescent Dye
|
|
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .
|
-
- HY-D2532
-
|
|
Fluorescent Dye
|
|
Cy5-PEG10000-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2589
-
|
|
Fluorescent Dye
|
|
Cy7.5 PEG-SH is a fluorescent labeling reagent that combines CY7.5 (HY-D0926) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em = 770/820 nm).
|
-
- HY-P11316
-
|
|
Fluorescent Dye
|
|
DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907)) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research .
|
-
- HY-D2883E
-
|
Rhodamine B-PEG5000-SH
|
Fluorescent Dye
|
|
RB-PEG5000-SH (Rhodamine B-PEG5000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883D
-
|
Rhodamine B-PEG3400-SH
|
Fluorescent Dye
|
|
RB-PEG3400-SH (Rhodamine B-PEG3400-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2509
-
|
|
Fluorescent Dye
|
|
Cy3-PEG1000-SH is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2883
-
|
Rhodamine B-PEG400-SH
|
Fluorescent Dye
|
|
RB-PEG400-SH (Rhodamine B-PEG400-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2530
-
|
|
Fluorescent Dye
|
|
Cy5-PEG3400-SH is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2883B
-
|
Rhodamine B-PEG1000-SH
|
Fluorescent Dye
|
|
RB-PEG1000-SH (Rhodamine B-PEG1000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883C
-
|
Rhodamine B-PEG2000-SH
|
Fluorescent Dye
|
|
RB-PEG2000-SH (Rhodamine B-PEG2000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883H
-
|
Rhodamine B-PEG10000-SH
|
Fluorescent Dye
|
|
RB-PEG10000-SH (Rhodamine B-PEG10000-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2883A
-
|
Rhodamine B-PEG600-SH
|
Fluorescent Dye
|
|
RB-PEG600-SH (Rhodamine B-PEG600-SH) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and sulfhydryl (SH). SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds (Ex/Em=546/610 nm) .
|
-
- HY-D2512
-
|
|
Fluorescent Dye
|
|
Cy3-PEG5000-SH is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2557
-
|
|
Fluorescent Dye
|
|
Cy5.5-PEG3400-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2559
-
|
|
Fluorescent Dye
|
|
Cy5.5-PEG10000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2558
-
|
|
Fluorescent Dye
|
|
Cy5.5-PEG5000-SH is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
|
-
- HY-D2925
-
|
dTCO-SNAP
|
Fluorescent Dye
|
|
dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .
|
-
- HY-D2763
-
|
|
Fluorescent Dye
|
|
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
|
| Cat. No. |
Product Name |
Type |
-
- HY-W020780
-
|
mPEG5000-Maleimide
|
Biochemical Assay Reagents
|
|
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .
|
-
- HY-166648
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .
|
-
- HY-W068119A
-
|
2-Maleimidoethylamine hydrochloride
|
Biochemical Assay Reagents
|
|
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .
|
-
- HY-174921A
-
|
|
Biochemical Assay Reagents
|
|
Maleimide-PEG2000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174953A
-
|
|
Biochemical Assay Reagents
|
|
TPP-PEG2000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-174953B
-
|
|
Biochemical Assay Reagents
|
|
TPP-PEG3400-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-W879049
-
|
DBCO-NHCO-PEG3-maleimide
|
Biochemical Assay Reagents
|
|
DBCO-PEG3-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-W440718C
-
|
|
Biochemical Assay Reagents
|
|
Cholesterol-PEG10000-Mal is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-174953
-
|
|
Biochemical Assay Reagents
|
|
TPP-PEG1000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-W588728
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG8-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
- HY-167036C
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG5000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG5000-Mal can be used for drug delivery .
|
-
- HY-W591465
-
|
4-Arm-PEG2000-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG2000-Maleimide (4-Arm-PEG2000-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W879036
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG8-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG8-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174927E
-
|
DBCO-PEG3400-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG3400-Maleimide (DBCO-PEG3400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927B
-
|
DBCO-PEG600-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG600-Maleimide (DBCO-PEG600-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG600-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927A
-
|
DBCO-PEG400-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG400-Maleimide (DBCO-PEG400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927D
-
|
DBCO-PEG2000-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG2000-Maleimide (DBCO-PEG2000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG2000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927H
-
|
DBCO-PEG10000-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG10000-Maleimide (DBCO-PEG10000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG10000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-W440722
-
|
|
Biochemical Assay Reagents
|
|
Cholesterol-PEG1000-Thiol is a PEGylated lipid that forms micelles in water and can be used to prepare liposomes or nanoparticles as drug delivery systems. The thiol moiety reacts with maleimide to form a stable thioether bond .
|
-
- HY-W588736
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG23-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
- HY-174921B
-
|
|
Biochemical Assay Reagents
|
|
Maleimide-PEG3400-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921C
-
|
|
Biochemical Assay Reagents
|
|
Maleimide-PEG5000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-174921
-
|
|
Biochemical Assay Reagents
|
|
Maleimide-PEG1000-COOH is a PEG derivative composed of Maleimide (HY-W007324), PEG units and carboxyl (-COOH). Carboxyl can easily form a stable amide bond with amino groups or an ester bond with hydroxyl groups. Maleimide forms a stable thioether bond with sulfhydryl (-SH) .
|
-
- HY-W441003
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-IA is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine.
|
-
- HY-167036A
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG1000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG1000-Mal can be used for drug delivery .
|
-
- HY-W591618D
-
|
4-Arm-PEG3400-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG3400-Maleimide (4-Arm-PEG3400-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W591618A
-
|
4-Arm-PEG400-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG400-Maleimide (4-Arm-PEG400-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W591618C
-
|
4-Arm-PEG1000-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG1000-Maleimide (4-Arm-PEG1000-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-W440902
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-IA is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage.
|
-
- HY-174927
-
|
DBCO-PEG5000-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG5000-Maleimide (DBCO-PEG5000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG5000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927C
-
|
DBCO-PEG1000-Mal
|
Biochemical Assay Reagents
|
|
DBCO-PEG1000-Maleimide (DBCO-PEG1000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG1000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174961C
-
|
Fmoc-NH-PEG5000-Mal
|
Biochemical Assay Reagents
|
|
Fmoc-PEG5000-Maleimide (Fmoc-NH-PEG5000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174961
-
|
Fmoc-NH-PEG1000-Mal
|
Biochemical Assay Reagents
|
|
Fmoc-PEG1000-Maleimide (Fmoc-NH-PEG1000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174953D
-
|
|
Biochemical Assay Reagents
|
|
TPP-PEG10000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-174953C
-
|
|
Biochemical Assay Reagents
|
|
TPP-PEG5000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-174809A
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG600-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809E
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG5000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809H
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG10000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG400-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809C
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG2000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809D
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG3400-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174809B
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG1000-Mal is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-167036D
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG10000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG10000-Mal can be used for drug delivery .
|
-
- HY-167036B
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG3400-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG3400-Mal can be used for drug delivery .
|
-
- HY-W591618B
-
|
4-Arm-PEG600-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG600-Maleimide (4-Arm-PEG600-Mal) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174961B
-
|
Fmoc-NH-PEG3400-Mal
|
Biochemical Assay Reagents
|
|
Fmoc-PEG3400-Maleimide (Fmoc-NH-PEG3400-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
-
- HY-174961A
-
|
Fmoc-NH-PEG2000-Mal
|
Biochemical Assay Reagents
|
|
Fmoc-PEG2000-Maleimide (Fmoc-NH-PEG2000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10375
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987 .
|
-
- HY-172320
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMS-986238 is an orally active macrocyclic peptide PD-L1 inhibitor. BMS-986238 can be used in the research of tumors such as solid tumors and lymphomas .
|
-
- HY-P3440
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PD-1/PD-L1
|
Cancer
|
|
WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression .
|
-
- HY-P10950A
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide TFA binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide TFA is promising for research of cancers .
|
-
- HY-P5963
-
-
- HY-P10950
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .
|
-
- HY-P5984
-
|
|
mTOR
|
Others
|
|
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
|
-
- HY-P10714
-
|
|
Proteasome
Apoptosis
Deubiquitinase
|
Cancer
|
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM .
|
-
- HY-P5984A
-
|
|
mTOR
|
Others
|
|
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
|
-
- HY-161096
-
|
|
ROR
|
Cancer
|
|
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines .
|
-
- HY-P11316
-
|
|
Biochemical Assay Reagents
Drug-Linker Conjugates for ADC
|
Others
|
|
DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab (HY-P9907)) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research .
|
-
- HY-P2331
-
|
Antibiotic A 3802-IV-3; Gardimycin
|
Antibiotic
|
Infection
|
|
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
|
-
- HY-P11673
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Zabopegdutide is a glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist. Zabopegdutide can be used for the study of obesity .
|
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P99685
-
|
IMGN-289; J2898A-SMCC-DM1
|
EGFR
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
|
Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research .
|
-
(5)
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-P10950
-
|
|
|
Alkynes
|
|
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .
|
-
- HY-W879049
-
|
DBCO-NHCO-PEG3-maleimide
|
|
DBCO
|
|
DBCO-PEG3-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-126781
-
|
BM-211290
|
|
Azide
|
|
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W588728
-
|
|
|
DBCO
|
|
DBCO-PEG8-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
- HY-W879036
-
|
|
|
DBCO
|
|
DBCO-PEG8-Maleimide is a PEG derivative consisting of DBCO, PEG units, and Maleimide (HY-W007324). NMaleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG8-Maleimide contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174927E
-
|
DBCO-PEG3400-Mal
|
|
DBCO
|
|
DBCO-PEG3400-Maleimide (DBCO-PEG3400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG3400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927B
-
|
DBCO-PEG600-Mal
|
|
DBCO
|
|
DBCO-PEG600-Maleimide (DBCO-PEG600-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG600-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927A
-
|
DBCO-PEG400-Mal
|
|
DBCO
|
|
DBCO-PEG400-Maleimide (DBCO-PEG400-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG400-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927D
-
|
DBCO-PEG2000-Mal
|
|
DBCO
|
|
DBCO-PEG2000-Maleimide (DBCO-PEG2000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG2000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927H
-
|
DBCO-PEG10000-Mal
|
|
DBCO
|
|
DBCO-PEG10000-Maleimide (DBCO-PEG10000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG10000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-W588736
-
|
|
|
DBCO
|
|
DBCO-PEG23-amine is a PEG derivative consisting of DBCO, PEG units and an amino group (Amine). Maleimide forms a stable thioether bond with sulfhydryl (-SH). The amino group can react with other chemical groups (such as carboxyl, aldehyde, etc.) to form stable chemical bonds.
|
-
- HY-174927
-
|
DBCO-PEG5000-Mal
|
|
DBCO
|
|
DBCO-PEG5000-Maleimide (DBCO-PEG5000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG5000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
-
- HY-174927C
-
|
DBCO-PEG1000-Mal
|
|
DBCO
|
|
DBCO-PEG1000-Maleimide (DBCO-PEG1000-Mal) is a PEG derivative composed of DBCO, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DBCO-PEG1000-Maleimide contains a DBCO group and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-166648
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .
|
-
- HY-W440719
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG2000-MAL is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.
|
-
- HY-166648A
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .
|
-
- HY-W440995
-
|
|
|
Pegylated Lipids
|
|
DOPE-PEG2000-Mal is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
|
-
- HY-W440718C
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG10000-Mal is a PEG derivative composed of Cholesterol, PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
|
-
- HY-167036C
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG5000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG5000-Mal can be used for drug delivery .
|
-
- HY-W440722
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG1000-Thiol is a PEGylated lipid that forms micelles in water and can be used to prepare liposomes or nanoparticles as drug delivery systems. The thiol moiety reacts with maleimide to form a stable thioether bond .
|
-
- HY-W440724
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG3400-Thiol is an amphiphatic PEG derivative which forms micelles in water and can be used to prepare liposomes or nanoparticles for drug delivery system. The thiol moiety is reactive with maleimide to form a stable thioether bond.
|
-
- HY-167036A
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG1000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG1000-Mal can be used for drug delivery .
|
-
- HY-W440727
-
|
|
|
Pegylated Lipids
|
|
Cholesterol-PEG2000-Vinylsulfone is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
|
-
- HY-167036D
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG10000-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG10000-Mal can be used for drug delivery .
|
-
- HY-167036B
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG3400-Mal is a PEG derivative composed of N,N-Dimethylglycine (DMG), PEG units and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. DMG-PEG3400-Mal can be used for drug delivery .
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent:
