2. Neuronal Signaling
  3. Serotonin Transporter
  4. Sertraline hydrochloride

セルトラリン塩酸塩  (Synonyms: Sertraline (hydrochloride))

製品番号: HY-B0176A 純度: 99.96%
COA 取扱説明書 Technical Support

Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.

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CAS 番号 : 79559-97-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
5 mg $60 在庫あり
10 mg $72 在庫あり
50 mg $230 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

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カスタマーレビュー

Based on 17 publication(s) in Google Scholar

Other Forms of Sertraline hydrochloride:

セルトラリン塩酸塩 関連抗体

Top Publications Citing Use of Products

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663.  [Abstract]

    Effects of Sertraline hydrochloride (100 μg/mL) on apoptosis of A549 cells after 48 h of incubation were observed.

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663.  [Abstract]

    Effects of Sertraline hydrochloride (100 μg/mL) combined with different concentrations of cisplatin (DDP) on the viability of A549 cells were observed.

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956.  [Abstract]

    U2OS GFP-RFP-LC3 cells were treated with either indatraline (10 μM) or Sertraline (10 μM) for 6 h.

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956.  [Abstract]

    Individual and mean tumor growth, as well as tumor-free survival of mice treated with sertraline, were assessed. The anti-tumor prophylactic activity of sertraline (20 μM) and indatraline-treated malignant cells was observed.

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230.  [Abstract]

    Representative Western blot of Iba-1, HMGB1,TNF-α, IL-1β and iNOS protein expression in the PFC. Protein levels are normalized to the levels of β-actin.

    Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230.  [Abstract]

    The number of neurons in the vehicle group is significantly decreased compared with the control group, whereas neuron numbers in the CUMS-exposed mice treated with arctiin and Sertraline hydrochloride (SERT) are apparently recovered. Annexin V expression in neurons of PFC is examined in mice by the double immunohistochemical staining.

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    製品説明

    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    Spermatozoa ED50
    0.04 %
    Compound: Sertraline.HCl
    Spermicidal activity against human spermatozoa
    Spermicidal activity against human spermatozoa
    		[PMID: 16464584]
    体外実験

    Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia[3].
    Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    セルトラリン塩酸塩 関連抗体
    体内実験

    Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice[3].
    Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals[4].
    Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Aromatase-knockout (Ar−/−) mice[4]
    Dosage: 10 mg/kg
    Administration: A single i.p. administration
    Result: Reduced the immobility time during FST in all genotypes, except male Ar+/− mice.
    臨床実験
    分子量

    342.69

    分子式

    C17H18Cl3N
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (145.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 2.86 mg/mL (8.35 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9181 mL 14.5904 mL 29.1809 mL
    5 mM 0.5836 mL 2.9181 mL 5.8362 mL
    10 mM 0.2918 mL 1.4590 mL 2.9181 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    濃度 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.96%

    COA (250 KB) HNMR (127 KB) RP-HPLC (243 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.9181 mL 14.5904 mL 29.1809 mL 72.9522 mL
    5 mM 0.5836 mL 2.9181 mL 5.8362 mL 14.5904 mL
    DMSO 10 mM 0.2918 mL 1.4590 mL 2.9181 mL 7.2952 mL
    15 mM 0.1945 mL 0.9727 mL 1.9454 mL 4.8635 mL
    20 mM 0.1459 mL 0.7295 mL 1.4590 mL 3.6476 mL
    25 mM 0.1167 mL 0.5836 mL 1.1672 mL 2.9181 mL
    30 mM 0.0973 mL 0.4863 mL 0.9727 mL 2.4317 mL
    40 mM 0.0730 mL 0.3648 mL 0.7295 mL 1.8238 mL
    50 mM 0.0584 mL 0.2918 mL 0.5836 mL 1.4590 mL
    60 mM 0.0486 mL 0.2432 mL 0.4863 mL 1.2159 mL
    80 mM 0.0365 mL 0.1824 mL 0.3648 mL 0.9119 mL
    100 mM 0.0292 mL 0.1459 mL 0.2918 mL 0.7295 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Sertraline hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sertraline79559-97-0Serotonin Transporter5-HTTSERTSLC6A4AntidepressantSSRIdisorderobsessiveInhibitorinhibitorinhibit

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    製品名:
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