Sibiromycin

Cat. No.: HY-N9460: Fiche technique Instruction de manipulation
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Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.

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Sibiromycin Chemical Structure

CAS No. : 12684-33-2

Size	Prix	Stock
1 mg		Demandez un devis et temps de livraison
5 mg		Demandez un devis et temps de livraison

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This product is a controlled substance and not for sale in your territory.

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	0.0014 μM Compound: 2	Cytotoxicity against human K562 cells after 96 hrs by alamar blue assay Cytotoxicity against human K562 cells after 96 hrs by alamar blue assay	[PMID: 20218628]

In Vitro

Pyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity^[1].
Alkylation of DNA by anthramycin, sibiromycin and tomaymycin is sequence specific with the following trend for binding preference 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py^[1].
Sibiromycin shows cytotoxicity against L1210 (leukemia), ADJ/PC6 (plasmacytoma) and CH1 (ovarian) cells with IC50s of ranging 0.000017 ~0.0029 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

475.53

Formule

C₂₄H₃₃N₃O₇

CAS No.

12684-33-2

SMILES

O=C1C2=CC(O[C@H]3[C@@H]([C@](O)([C@H]([C@@H](O3)C)NC)C)O)=C(C)C(O)=C2N[C@@H]([C@@]4([H])N1C=C(C4)/C=C/C)O

Structure Classification

Initial Source

Microorganisms

Streptosporangium sibiricum

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293. [Content Brief]

[2]. Li W, et al. Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol. 2009;75(9):2869-2878. [Content Brief]

Sibiromycin Related Classifications

Calculateur de molarité
Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sibiromycin12684-33-2DNA Alkylator/CrosslinkerAntibioticpyrrolobenzodiazepinesantitumorgrooveDNAguaninealkylatingInhibitorinhibitorinhibit

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