2. Apoptosis
  3. Apoptosis
  4. Stevioside

ステビオシド  (Synonyms: Stevioside)

製品番号: HY-N0669 純度: 99.32%
COA 取扱説明書 Technical Support

Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 57817-89-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
10 mg $25 在庫あり
25 mg $45 在庫あり
50 mg $65 在庫あり
100 mg $95 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Stevioside:

ステビオシド 関連抗体

Top Publications Citing Use of Products

    Stevioside purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Feb 13:2025:7942947.  [Abstract]

    Stevioside (SV, 2.5-5 μM). CCK8 assay of cell viability of HFP-induced-HepG2 cells treated with different concentrations of SeNPs and SV-SeNPs for 48 h.

    Stevioside purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Feb 13:2025:7942947.  [Abstract]

    Stevioside (SV, 2.5-5 μM). The changes of lipid droplets in HFP-induced-HepG2 cells after SeNPs and SV-SeNPs treatment for 48 h were tested by oil red O staining.

    Stevioside purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Feb 13:2025:7942947.  [Abstract]

    Stevioside (SV, 2.5-5 μM). Determination of TG content in HFP-induced-HepG2 cells incubated with SeNPs and SV-SeNPs for 48 h. The data represent the mean ± SD of three independent experiments.

    Stevioside purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Feb 13:2025:7942947.  [Abstract]

    Stevioside (SV, 2.5-5 μM). SV-SeNPs relieve cell steatosis by modulation of lipid metabolic gene expression in HFP-treated HepG2 cells. HFP-induced-HepG2 cells were incubated with SeNPs and SV-SeNPs for 48 h and followed by q-PCR analysis of the mRNA expression of ACC1, FASN, SCD1, SREBP1.

    Stevioside purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Feb 13:2025:7942947.  [Abstract]

    Stevioside (SV, 2.5-5 μM). Effects of SV-SeNPs on PI3K/AKT/Nrf2 signaling pathway and PPARα in HFP-treated HepG2 cells. (A) HFP-induced-HepG2 cells were incubated with SeNPs and SV-SeNPs for 48 h and followed by western blot analysis of expression of P-PI3K, P-AKT, Nrf2, and PPARα.

    Stevioside purchased from MedChemExpress. Usage Cited in: J Orthop Translat. 2022 Nov 15:38:190-202.

    Stevioside (STE; 10, 20, 40 µM) significantly decreases the expression of iNOS and COX-2 in a dose-dependent manner compared to stimulation with IL-1β.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    Raji IC50
    360 μM
    Compound: 1
    Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique
    Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique
    		[PMID: 19131254]
    体外実験

    Stevioside (10 μM, 24-48 h) can enhance cytotoxicity of 5-Fluorouracil (5-Fu, HY-90006) to MDA-MB-231 and SKBR3cells[1].
    Stevioside (10 μM, 48 h) combinated with 5-Fu (HY-90006) could increase the ratio of Bax to Bcl-2 in MDA-MB-231 cells, thereby triggering apoptosis[1].
    Stevioside (10-1000 μM, 6 h) induces TNF-α and IL-1β release in THP-1 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ステビオシド 関連抗体

    Apoptosis Analysis[1]

    Cell Line: MDA-MB-231
    Concentration: 10 μM
    Incubation Time: 24 h
    Result: Increased the rate of apoptosis in cells with combination of 5-Fu (HY-90006).
    Increased ROS level significantly in MDA-MB-231.
    Combinated with 5-Fu (HY-90006) could trigger early and late apoptotic events in cancer cells.

    Western Blot Analysis[2]

    Cell Line: THP-1 cells
    Concentration: 1 mM
    Incubation Time: 45 min
    Result: Inhibited the expression level of NF-κB and IKKβ.
    体内実験

    Stevioside (20 mg/kg, p.o., daily, 10 days) prevents significant increase in glycaemia in NMRI Haan mice[3].
    Stevioside (50-200 mg/kg, i.v., one time) reduces blood pressure in a dose-dependent manner in spontaneously hypertensive rats[4].
    Stevioside (6.25-25 mg/kg, p.o., daily, 15 days) increases the proliferative response of in LPS stimulated B-lymphocytes in Balb/c mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Balb/c mice[5]
    Dosage: 6.25-25 mg/kg
    Administration: p.o., daily, 7 days
    Result: Didn’t show any change in the general behaviour of the test animals.
    Increased antibody synthesis of 15.38% and delayed type hypersensitivity (DTH) response of 18% at the dose of 12.5 mg/kg.
    Possessed macrophage stimulatory activity and increased phagocytic index.
    臨床実験
    分子量

    804.87

    分子式

    C38H60O18
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=O)[C@@]4([H])[C@]2(CC5=C)C[C@@]5(O[C@@](O[C@H](CO)[C@@H](O)[C@@H]6O)([H])[C@@H]6O[C@]([C@@H]([C@@H](O)[C@@H]7O)O)([H])O[C@@H]7CO)CC4
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 175 mg/mL (217.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2424 mL 6.2122 mL 12.4244 mL
    5 mM 0.2485 mL 1.2424 mL 2.4849 mL
    10 mM 0.1242 mL 0.6212 mL 1.2424 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.32%

    COA (265 KB) HNMR (316 KB) LCMS (89 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.2424 mL 6.2122 mL 12.4244 mL 31.0609 mL
    5 mM 0.2485 mL 1.2424 mL 2.4849 mL 6.2122 mL
    10 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1061 mL
    15 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0707 mL
    20 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5530 mL
    25 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
    30 mM 0.0414 mL 0.2071 mL 0.4141 mL 1.0354 mL
    40 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7765 mL
    50 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
    60 mM 0.0207 mL 0.1035 mL 0.2071 mL 0.5177 mL
    80 mM 0.0155 mL 0.0777 mL 0.1553 mL 0.3883 mL
    100 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.3106 mL
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    Stevioside Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Stevioside57817-89-7Apoptosisantihypertensiveantihyperglycemicantioxidantanti-inflammatoryanti-tumorsweetenerchemosensitization5-FUInhibitorinhibitorinhibit

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    製品名:
    Stevioside
    製品番号:
    HY-N0669
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