Trifolium hybridum L.

Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities.

Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC₅₀ value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity.

Rebaudioside C (Dulcoside B) is an orally effective natural sweetener that cannot pass the blood-brain barrier and selectively binds to human sweet taste receptors (TAS1R2/TAS1R3). The sweetness of Rebaudioside C is about 20-30 times that of sucrose, and its sweetness activity depends on the C-16/C-17 double bond structure and specific aglycones. The glycoside structure in the Rebaudioside C molecule can bind to the sweet taste receptor, activate the taste signal transduction pathway, and produce sweetness perception.

Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .

Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer.

Rebaudioside C (Standard) is the analytical standard of Rebaudioside C. This product is intended for research and analytical applications. Rebaudioside C (Dulcoside B) is a natural sweetener that can be used in controlled diets for diabetic patients.

Rebaudioside B is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni. Rebaudioside B tastes about 150 times sweeter than sucrose. Rebaudioside B can hydrolysis to steviol.

Sterebin E is a labdane diterpenoid that can be found in Stevia rebaudiana leaves.