Rebaudioside M
Based on 1 publication(s) in Google Scholar
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 1220616-44-3
- Formula: C56H90O33
- Molecular Weight:1291.29
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Rebaudioside M
More
Biological Activity
Rebaudioside M demonstrates to protect β-cell activity and enhance insulin secretion via increasing calcium influx into β-cells[3].
Rebaudioside M inhibits the PI3K/Akt signaling pathway resulting in lower cell proliferation and enhanced apoptosis and downregulates the Wnt/catenin signaling pathway in colon cancer cells, which is linked to reduced cell migration and invasion[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rebaudioside M decreases oxidative stress and the production of pro-inflammatory cytokines in diabetic rats, protecting against pancreatic beta-cell damage[4].
Rebaudioside M reduces blood pressure via the suppression of angiotensin-converting enzyme, increases endothelial function and causes vasodilation in hypertensive rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1220616-44-3
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Appearance Solid
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Molecular Weight 1291.29
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Formula C56H90O33
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Color White to off-white
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SMILES
C[C@]12[C@@]3([H])[C@@](C4)(CC[C@]1([H])[C@@](C)(CCC2)C(O[C@H]5[C@@H]([C@H]([C@H](O)[C@@H](CO)O5)O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)CO)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)=O)C[C@@](C4=C)(O[C@@]8([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O8)O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)O[C@]%10([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]%10O)CO)CC3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (77.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Prakash I, et al. Development of Next Generation Stevia Sweetener: Rebaudioside M. Foods. 2014 Feb 27;3(1):162-175. [Content Brief]
[3]. Jeppesen PB, et al. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism. 2000 Feb;49(2):208-14. [Content Brief]
[5]. Chakraborty R, et al. Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications[J]. Journal of Integrative Medicine, 2021, 19(6): 478-492. [Content Brief]
[6]. Iatridis N, et al. Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener. Molecules. 2022 Feb 17;27(4):1362. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7744 mL | 3.8721 mL | 7.7442 mL | 19.3605 mL |
| 5 mM | 0.1549 mL | 0.7744 mL | 1.5488 mL | 3.8721 mL | |
| 10 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9360 mL | |
| 15 mM | 0.0516 mL | 0.2581 mL | 0.5163 mL | 1.2907 mL | |
| 20 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9680 mL | |
| 25 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
| 30 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6453 mL | |
| 40 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL | |
| 50 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL | |
| 60 mM | 0.0129 mL | 0.0645 mL | 0.1291 mL | 0.3227 mL |
Rebaudioside M Related Classifications
HY-N6833 Related Classifications
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