2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Unifiram

Unifiram (DM232) is a AMPA receptor activator and cognitive enhancer. Unifiram activates the AMPA-mediated neurotransmission system. Unifiram reverses NBQX-induced amnesia in the passive avoidance test in mice. Unifiram reverses the antagonistic effect of kynurenic acid on NMDA-mediated [3H]NA release in rat hippocampal slices. Unifiram enhances excitatory synaptic transmission in the rat hippocampus in vitro. Unifiram can be used in studies related to amnesia and cognitive dysfunction, including age-related memory decline, neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease, multiple sclerosis, schizophrenia, and attention deficit hyperactivity disorder.

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Unifiram

Unifiram 構造式

CAS 番号 : 272786-64-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
10 mg $25 在庫あり
25 mg $43 在庫あり
50 mg $70 在庫あり
100 mg $115 在庫あり
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500 mg   お問い合わせ  

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Unifiram 関連抗体

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製品説明

Unifiram (DM232) is a AMPA receptor activator and cognitive enhancer. Unifiram activates the AMPA-mediated neurotransmission system. Unifiram reverses NBQX-induced amnesia in the passive avoidance test in mice. Unifiram reverses the antagonistic effect of kynurenic acid on NMDA-mediated [3H]NA release in rat hippocampal slices. Unifiram enhances excitatory synaptic transmission in the rat hippocampus in vitro. Unifiram can be used in studies related to amnesia and cognitive dysfunction, including age-related memory decline, neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease, multiple sclerosis, schizophrenia, and attention deficit hyperactivity disorder[1][2].

IC50 & Target[1]

AMPA Receptor

 

NMDA Receptor

 

体外実験

Unifiram (0-1 µM; 30-95 min of superfusion) reverses the inhibitory effect of Kynurenic acid (HY-100806) on NMDA-evoked [3H]NA release in rat hippocampal slices via an AMPA receptor-dependent mechanism, with an EC50 ≤ 0.1 µM[1].
Unifiram (10 nM-1 µM; 15 min per concentration in a cumulative sequence) induces a persistent, concentration-dependent increase in fEPSP amplitude in the CA1 region of rat hippocampal slices, with an EC50 of 27 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Unifiram 関連抗体
体内実験

Unifiram (0.01-10 mg/kg, i.p.; single administration) reverses NBQX (HY-15068)-induced memory impairment in *Mus musculus* mice, and does not impair motor coordination or alter spontaneous behaviors at the dose of 0.1 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (male, 23-30 g)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 10 mg/kg
Administration: i.p.; single dose
Result: Restored entrance latency in the retention test to levels comparable to saline-treated control mice at 0.1 mg/kg.
Showed no effect on NBQX-induced amnesia at 0.01 mg/kg.
Did not modify endurance time on the rota rod test at 0.1 mg/kg and 10 mg/kg.
Did not alter spontaneous motility or inspection activity in the hole board test at 0.1 mg/kg and 10 mg/kg.
Did not enhance entrance latency in unamnesic mice.
分子量

298.34

分子式

C13H15FN2O3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1CCC2CN(S(=O)(C3=CC=C(F)C=C3)=O)CCN21
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (167.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3519 mL 16.7594 mL 33.5188 mL
5 mM 0.6704 mL 3.3519 mL 6.7038 mL
10 mM 0.3352 mL 1.6759 mL 3.3519 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3519 mL 16.7594 mL 33.5188 mL 83.7970 mL
5 mM 0.6704 mL 3.3519 mL 6.7038 mL 16.7594 mL
10 mM 0.3352 mL 1.6759 mL 3.3519 mL 8.3797 mL
15 mM 0.2235 mL 1.1173 mL 2.2346 mL 5.5865 mL
20 mM 0.1676 mL 0.8380 mL 1.6759 mL 4.1899 mL
25 mM 0.1341 mL 0.6704 mL 1.3408 mL 3.3519 mL
30 mM 0.1117 mL 0.5586 mL 1.1173 mL 2.7932 mL
40 mM 0.0838 mL 0.4190 mL 0.8380 mL 2.0949 mL
50 mM 0.0670 mL 0.3352 mL 0.6704 mL 1.6759 mL
60 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3966 mL
80 mM 0.0419 mL 0.2095 mL 0.4190 mL 1.0475 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.8380 mL
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Unifiram Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Unifiram272786-64-8DM232DM 232DM-232iGluRIonotropic glutamate receptorsmouse passive avoidance testscognitive dysfunctionsalzheimer’s diseasekynurenic acidrat hippocampal slicesrodentsAMPA receptorNBQXNMDAamnesiaInhibitorinhibitorinhibit

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