2. Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. Proteasome Apoptosis Parasite
  4. Z-LLY-FMK

Z-LLY-FMK  (Synonyms: Calpain Inhibitor IV)

製品番号: HY-136750 純度: 98.65%
COA 取扱説明書 Technical Support

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis.

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Z-LLY-FMK

Z-LLY-FMK 構造式

CAS 番号 : 133410-84-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 344 在庫あり
Solution
10 mM * 1 mL in DMSO USD 344 在庫あり
Solid
5 mg $280 在庫あり
10 mg $450 在庫あり
25 mg $900 在庫あり
50 mg $1450 在庫あり
100 mg $2350 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Z-LLY-FMK 関連抗体

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Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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製品説明

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3].

IC50 & Target

Calpain[1]
体外実験

Z-LLY-FMK (10 μM, 1 h pretreatment) inhibits Gal-9-induced apoptosis in MOLT-4 cells in a time- and dose-dependent manner[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z-LLY-FMK 関連抗体
体内実験

Z-LLY-FMK (0.5 mg, via inferior vena cava immediately after common bile duct ligation, then 0.5 mg i.p. twice daily on days 1-2, and 0.5 mg i.p. on the morning of day 3) effectively diminishes hepatocyte apoptosis and ductular proliferation in common bile duct-ligated rats[1].
Z-LLY-FMK (2.2 μg, i.p., daily, starting 2 days pre-infection and continuing for 30 days post-challenge) achieves an 80% reduction in parasite burden in BALB/c mice challenged with 10 Taenia crassiceps cysts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) underwent common bile duct ligation (double-ligated with 50 silk and divided between ligatures) to establish a model of extrahepatic cholestasis[1].
Dosage: 0.5 mg
Administration: 0.5 mg via inferior vena cava immediately after common bile duct ligation, then 0.5 mg i.p. twice daily on days 1-2, and 0.5 mg i.p. on the morning of day 3
Result: Significantly diminished hepatocyte apoptosis in common bile duct-ligated rats.
Markedly reduced ductular proliferation in common bile duct-ligated rats.
Animal Model: Taenia crassiceps cysts (10 in 200 µL phosphate-buffered saline) were intraperitoneally challenged into BALB/c mice[2]
Dosage: 2.2 μg
Administration: i.p., daily starting 2 days pre-infection and continuing for 30 days post-challenge
Result: Achieved an 80% reduction in parasite burden in BALB/c mice.
Showed no obvious toxicity.
Caused cysts to exhibit degenerative changes including tegumental erosion, shortened or sloughed microtriches, and breaks in the cyst surface.
Led to an intense but focal inflammatory reaction on cyst surfaces, with presence of fibroblasts, collagen, neutrophils, and macrophages.
分子量

557.65

分子式

C30H40FN3O6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(CF)[C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(C=C2)=CC=C2O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (224.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7932 mL 8.9662 mL 17.9324 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL
10 mM 0.1793 mL 0.8966 mL 1.7932 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7932 mL 8.9662 mL 17.9324 mL 44.8310 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL 8.9662 mL
10 mM 0.1793 mL 0.8966 mL 1.7932 mL 4.4831 mL
15 mM 0.1195 mL 0.5977 mL 1.1955 mL 2.9887 mL
20 mM 0.0897 mL 0.4483 mL 0.8966 mL 2.2415 mL
25 mM 0.0717 mL 0.3586 mL 0.7173 mL 1.7932 mL
30 mM 0.0598 mL 0.2989 mL 0.5977 mL 1.4944 mL
40 mM 0.0448 mL 0.2242 mL 0.4483 mL 1.1208 mL
50 mM 0.0359 mL 0.1793 mL 0.3586 mL 0.8966 mL
60 mM 0.0299 mL 0.1494 mL 0.2989 mL 0.7472 mL
80 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5604 mL
100 mM 0.0179 mL 0.0897 mL 0.1793 mL 0.4483 mL
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Z-LLY-FMK Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-LLY-FMK133410-84-1Calpain Inhibitor IVProteasomeApoptosisParasiteObstructive jaundiceCalpainInhibitorinhibitorinhibit

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