133410-84-1
Chemical Structure
Z-LLY-FMK
Synonym(s): Calpain Inhibitor IV
- CAS No.: 133410-84-1
- Formula:C30H40FN3O6
- Molecular Weight:557.65
IUPAC Name: benzyl ((S)-1-(((S)-1-(((S)-4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
InChIKey: JCRSHQCFRMCMOC-GSDHBNRESA-N
SMILES: O=C(CF)[C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(C=C2)=CC=C2O
Biological Activity: Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-LLY-FMK | 98.65% | Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis. | ||||||||||||||||||||
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- [1]. Sheen-Chen SM, et al. Z-LLY-FMK can attenuate hepatocyte apoptosis after bile duct ligation in rat. Dig Dis Sci. 2008 Nov;53(11):2975-9. [Content Brief]
- [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8. [Content Brief]
- [3]. Kashio Y, et al. Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol. 2003 Apr 1;170(7):3631-6. [Content Brief]
Keywords
