2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1-Palmitoyl-sn-glycero-3-phosphocholine

1-Palmitoyl-sn-glycero-3-phosphocholine  (Synonyms: 16:0 Lyso PC)

製品番号: HY-125783 純度: 99.92%
COA 取扱説明書 Technical Support

1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis.

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1-Palmitoyl-sn-glycero-3-phosphocholine

1-Palmitoyl-sn-glycero-3-phosphocholine 構造式

CAS 番号 : 17364-16-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in Water USD 55 在庫あり
Solid
25 mg $50 在庫あり
50 mg $80 在庫あり
100 mg $125 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of 1-Palmitoyl-sn-glycero-3-phosphocholine:

1-Palmitoyl-sn-glycero-3-phosphocholine 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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製品説明

1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

1-Palmitoyl-sn-glycero-3-phosphocholine (125 μM, 2 h) induces superoxide overload on HUVECs by inhibiting SOD1. The levels of phosphoryl-ERK1/2 and eNOS were down-regulated[1].
1-Palmitoyl-sn-glycero-3-phosphocholine (0.3, 1 μM, 24 h) can enhance the secretion of IL-6, IL-1β, IL-12 and TNF-α in LPS (HY-D1056)-stimulated M1 macrophages[2].
1-Palmitoyl-sn-glycero-3-phosphocholine (10 μM, 24 h) increases TGF-β1 production and Foxp3 protein level in isolated human peripheral blood Treg cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Palmitoyl-sn-glycero-3-phosphocholine 関連抗体

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 50, 100, 125, 150 μM
Incubation Time: 2 h
Result: Inhibited cell viability in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 50, 100, 125, 150 μM
Incubation Time: 0.5, 1, 2 h
Result: Time-dependently decreased protein levels of eNOS and SOD1.
体内実験

1-Palmitoyl-sn-glycero-3-phosphocholine (10 mg/kg, subcutaneous injection) enhances neutrophil function, bacterial clearance, and survival in a mouse model of sepsis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cecal ligation and puncture (CLP) mice[4]
Dosage: 10 mg/kg
Administration: s.c.
Result: Increased bactericidal activity of neutrophils, but not macrophages, by enhancing H(2)O(2) production in neutrophils that ingested E. coli.
分子量

495.63

分子式

C24H50NO7P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (100.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0176 mL 10.0882 mL 20.1763 mL
5 mM 0.4035 mL 2.0176 mL 4.0353 mL
10 mM 0.2018 mL 1.0088 mL 2.0176 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (100.88 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.92%

COA (240 KB) HNMR (261 KB) CNMR (237 KB) RP-HPLC (239 KB) MS (85 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0176 mL 10.0882 mL 20.1763 mL 50.4409 mL
5 mM 0.4035 mL 2.0176 mL 4.0353 mL 10.0882 mL
10 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0441 mL
15 mM 0.1345 mL 0.6725 mL 1.3451 mL 3.3627 mL
20 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5220 mL
25 mM 0.0807 mL 0.4035 mL 0.8071 mL 2.0176 mL
30 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.6814 mL
40 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2610 mL
50 mM 0.0404 mL 0.2018 mL 0.4035 mL 1.0088 mL
60 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8407 mL
80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Palmitoyl-sn-glycero-3-phosphocholine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Palmitoyl-sn-glycero-3-phosphocholine17364-16-816:0 Lyso PCEndogenous MetaboliteLysophosphatidylcholineHUVECsM1 macrophagesTreg cellsInhibitorinhibitorinhibit

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製品名:
1-Palmitoyl-sn-glycero-3-phosphocholine
製品番号:
HY-125783
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