2. Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR
  3. Drug Metabolite Bcl-2 Family Akt Apoptosis
  4. 15(S)-HPETE

15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies.

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15(S)-HPETE

15(S)-HPETE Chemical Structure

CAS No. : 70981-96-3

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15(S)-HPETE Related Antibodies

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Description

15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies[1][2][3].

Cellular Effect
Cell Line Type Value Description References
RBL-1 IC50
3.4 3
Compound: 3
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
[PMID: 3806609]
RBL-1 IC50
3.4 3
Compound: 3
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
[PMID: 3806609]
In Vitro

15(S)-HPETE (0.1 μM; 24 h) reverses the pro-angiogenic effect of 15(S)-HETE in HUVECs, with reducing CD31 and VEGF production[1].
15(S)-HPETE (0.1 μM) significantly inhibits endothelial cell sprouting from rat epididymal adipose tissue explants[2].
15(S)-HPETE (1-20 μM; 3-24 h) inhibits the viability of K-562 cells (chronic myeloid leukemia cells) and induced their apoptosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15(S)-HPETE Related Antibodies

Western Blot Analysis[2]

Cell Line: Adipose-derived endothelial cells (isolated from rat epididymal fat pads)
Concentration: 0.1 μM
Incubation Time: 48 h
Result: Showed a decrease in Bcl-2 protein level with no change in Bax level.
Showed a reduction in Akt protein level and its phosphorylation level.
Masse moléculaire

336.47

Formule

C20H32O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC[C@H](OO)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Solution, -20°C, 2 years
Pureté et documentation

Purity: 97.32%

SDS (604 KB)

COA (239 KB) RP-HPLC (240 KB) MS (130 KB)

Instruction de manipulation (2659 KB)
Références
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15(S)-HPETE Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15(S)-HPETE70981-96-3Drug MetaboliteBcl-2 FamilyAktApoptosisPKBProtein kinase BHUVECendothelial celladipose tissueK-562anti-angiogenicInhibitorinhibitorinhibit

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