70981-96-3
Chemical Structure
15(S)-HPETE
- CAS No.: 70981-96-3
- Formula:C20H32O4
- Molecular Weight:336.47
IUPAC Name: (S,5Z,8Z,11Z,13E)-15-hydroperoxyicosa-5,8,11,13-tetraenoic acid
InChIKey: BFWYTORDSFIVKP-VAEKSGALSA-N
SMILES: CCCCC[C@H](OO)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Biological Activity:
15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies[1][2][3].
The product specifications provided below refer solely to the active content of 15(S)-HPETE.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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15(S)-HPETE | 97.32% | 15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies. The product specifications provided below refer solely to the active content of 15(S)-HPETE. |
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-
Similarity Score 0.97
HY-1257705(S)-HPETE -
Similarity Score 0.92
HY-13814813(S)-HPOTrE(γ) -
Similarity Score 0.90
HY-11333615(S)-HETE -
Similarity Score 0.90
HY-113336A15(R)-HETE -
Similarity Score 0.90
HY-113336B(±)15-HETE -
Similarity Score 0.89
HY-11344312(S)-HPETE -
Similarity Score 0.89
HY-113443A12(R)-HPETE -
Similarity Score 0.89
HY-1583678(R)-HPETE -
Similarity Score 0.89
HY-N165148(S)-HPETE -
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References
- [1]. Soumya SJ, et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. Inflamm Res. 2012 Jul;61(7):707-18. [Content Brief]
- [2]. Soumya SJ, et al. 15-LOX metabolites and angiogenesis: angiostatic effect of 15(S)-HPETE involves induction of apoptosis in adipose endothelial cells. PeerJ. 2014 Oct 21;2:e635. [Content Brief]
- [3]. Mahipal SV, et al. Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. Biochem Pharmacol. 2007 Jul 15;74(2):202-14. [Content Brief]
