5(S)-HPETE
Based on 1 publication(s) in Google Scholar
5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 71774-08-8
- Formula: C20H32O4
- Molecular Weight:336.47
-
Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 5(S)-HPETE
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
|
Human Endogenous Metabolite |
5(S)-HpETE (1-30 μM) acts as a substrate for recombinant human 5-LOX-mediated epoxidation, with a Km of 14 μM in the absence of ATP, and ATP induces 4.8-fold activation of Vmax and 3.9-fold activation of Vmax/Km for this reaction[1].
5(S)-HPETE (0.5-40 μM) acts as a substrate for human h12-LOX, with a kcat/KM of 0.13 s−1 μM−1[2].
5(S)-HPETE (0.5-40 μM) acts as a substrate for human h15-LOX-1, with a kcat/KM of 0.23 s−1 μM−1, and the enzyme exhibits altered positional specificity to produce mostly 5S,12S-diHpETE[2].
5(S)-HPETE (0.5-40 μM) acts as a substrate for human h15-LOX-2, with a kcat/KM of 0.035 s−1 μM−1, and the enzyme maintains strict positional specificity to produce only 5S,15S-diHpETE[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 71774-08-8
-
Appearance Liquid
-
Molecular Weight 336.47
-
Formula C20H32O4
-
Color Colorless to light yellow
-
SMILES
CCCCC/C=C\C/C=C\C/C=C\C=C\[C@@H](OO)CCCC(O)=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Solution, -20°C, 2 years
Publications (1)
-
Journal Impact Factor
-
Most Recent
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (544 KB)
- English - EN (544 KB)
- Français - FR (544 KB)
- Deutsch - DE (544 KB)
- Norwegian - NO (544 KB)
- Español - ES (544 KB)
- Swedish - SV (544 KB)
- Italian - IT (544 KB)
- Korean - KR (544 KB)
- Portuguese - PT (544 KB)
-
Handling Instructions (2659 KB)
References
[1]. Smyrniotis CJ, et al. ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry. 2014 Jul 15;53(27):4407-19. [Content Brief]
[2]. Perry SC, et al. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. 2020;59(42):4118-4130. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5(S)-HPETE Related Classifications
HY-125770 Related Classifications
Powered by Bioz