71774-08-8
Chemical Structure
5(S)-HPETE
- CAS No.: 71774-08-8
- Formula:C20H32O4
- Molecular Weight:336.47
IUPAC Name: (S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
InChIKey: JNUUNUQHXIOFDA-JGKLHWIESA-N
SMILES: CCCCC/C=C\C/C=C\C/C=C\C=C\[C@@H](OO)CCCC(O)=O
Biological Activity: 5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis[1][2].
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5(S)-HPETE | 98.0% | 5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis. | ||||||||||||||||||||
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- [1]. Smyrniotis CJ, et al. ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry. 2014 Jul 15;53(27):4407-19. [Content Brief]
- [2]. Perry SC, et al. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. 2020;59(42):4118-4130. [Content Brief]
Keywords
