15(S)-HPETE
Based on 1 Customer Validation
15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies.
For research use only. We do not sell to patients.
- Purity: 97.32%
- CAS No.: 70981-96-3
- Formula: C20H32O4
- Molecular Weight:336.47
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | IC50 |
3.4 μM
Compound: 3
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Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
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[PMID: 3806609] |
15(S)-HPETE (0.1 μM; 24 h) reverses the pro-angiogenic effect of 15(S)-HETE in HUVECs, with reducing CD31 and VEGF production[1].
15(S)-HPETE (0.1 μM) significantly inhibits endothelial cell sprouting from rat epididymal adipose tissue explants[2].
15(S)-HPETE (1-20 μM; 3-24 h) inhibits the viability of K-562 cells (chronic myeloid leukemia cells) and induced their apoptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Adipose-derived endothelial cells (isolated from rat epididymal fat pads)
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Concentration:0.1 μM
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Incubation Time:48 h
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Result:Showed a decrease in Bcl-2 protein level with no change in Bax level.
Showed a reduction in Akt protein level and its phosphorylation level.
Chemical Information
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CAS No. 70981-96-3
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Appearance Liquid
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Molecular Weight 336.47
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Formula C20H32O4
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Color Colorless to light yellow
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SMILES
CCCCC[C@H](OO)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (265 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Portuguese - PT (604 KB)
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Handling Instructions (2659 KB)
References
[1]. Soumya SJ, et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. Inflamm Res. 2012 Jul;61(7):707-18. [Content Brief]
[2]. Soumya SJ, et al. 15-LOX metabolites and angiogenesis: angiostatic effect of 15(S)-HPETE involves induction of apoptosis in adipose endothelial cells. PeerJ. 2014 Oct 21;2:e635. [Content Brief]
[3]. Mahipal SV, et al. Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. Biochem Pharmacol. 2007 Jul 15;74(2):202-14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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