2'-Deoxyguanosine (Synonyms: Deoxyguanosine; Guanine deoxyriboside)

Name: 2'-Deoxyguanosine
Brand: MedChemExpress
SKU: HY-17563
Rating: 5.0 (6 reviews)

製品番号: HY-17563 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells.

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CAS 番号 : 961-07-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$50	在庫あり	Estimated Time of Arrival: December 31
1 g	$70	在庫あり	Estimated Time of Arrival: December 31
5 g	$150	在庫あり	Estimated Time of Arrival: December 31
10 g	$230	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of 2'-Deoxyguanosine:

顧客検証

Microbiological Assay

ELISA

: 2'-Deoxyguanosine purchased from MedChemExpress. Usage Cited in: PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]; The effect of supplementing OP50-enriched metabolites to HT115 diet on the developmental rate of chca-1 mutant worms.
Each metabolite was added to HT115 and seeded on NGM plates at 20 mM or their saturating concentration (final concentration: 20 mM spermidine, 6 mM thymidine, 20 mM GSSG, 20 mM 2’-deoxyuridine, 6 mM N(1)-acetylspermine, 4 mM 2’-Deoxyguanosine, 6 mM adenosine-2’,3’-cyclic monophosphate, 1 mM 2’-deoxyinosine, 20 mM spermine). Synchronized eggs were seeded on the prepared plates to record developmental rate.

: 2'-Deoxyguanosine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 31;30(13):4370-4385.e7. [Abstract]; THP-1PMA 167 cells were infected by SFTSV (MOI = 10) for 24 hours in the presence of 2'-Deoxyguanosine (dG) or 8-OH-dG. P17 in the supernatants or pro-IL-1β in the cell lysate was determined by western blot.

: 2'-Deoxyguanosine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 31;30(13):4370-4385.e7. [Abstract]; THP-1PMA 167 cells were infected by SFTSV (MOI = 10) for 24 hours in the presence of 2'-Deoxyguanosine (dG) or 8-OH-dG. IL-1β levels in the supernatants were determined by ELISA.

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	>250 μM Compound: 2'-Deoxyguanosine	Cytotoxicity against rat C6 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	10.1039/C3MD00159H
CCRF-HSB-2	IC₅₀	2.8 μg/mL Compound: araG	Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells. Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells.	[PMID: 9216836]
DU-145	IC₅₀	>250 μM Compound: 2'-Deoxyguanosine	Cytotoxicity against human DU145 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	10.1039/C3MD00159H
HaCaT	IC₅₀	>250 μM Compound: 2'-Deoxyguanosine	Cytotoxicity against human HaCaT cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as inhibition of cell viability after 48 hrs by MTT assay	10.1039/C3MD00159H
HEL	ED₅₀	10.1 μg/mL Compound: araG	Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells. Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	16.8 μg/mL Compound: araG	Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells. Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	55 μg/mL Compound: araG	Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells. Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	78 μg/mL Compound: araG	Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells. Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
L6	IC₅₀	>250 μM Compound: 2'-Deoxyguanosine	Cytotoxicity against rat L6 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against rat L6 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	10.1039/C3MD00159H
MCF7	IC₅₀	>250 μM Compound: 2'-Deoxyguanosine	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	10.1039/C3MD00159H
MT4	ED₅₀	158 μM Compound: 11c	Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells. Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.	[PMID: 3172142]

体外実験

2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC₅₀ values of 50 and 80 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

267.25

分子式

C₁₀H₁₃N₅O₄

CAS 番号

961-07-9

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O[C@H](C1)N2C3=C(N=C2)C(NC(N)=N3)=O)[C@H]1O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (374.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7418 mL	18.7091 mL	37.4181 mL
5 mM	0.7484 mL	3.7418 mL	7.4836 mL
10 mM	0.3742 mL	1.8709 mL	3.7418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.35 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.96%

Select Batch:

データシート (275 KB) SDS (393 KB)

COA (249 KB) HNMR (122 KB) RP-HPLC (283 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ross DD, et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 1981 Nov;41(11 Pt 1):4493-8. [Content Brief]

[2]. Kizaki H, et al. Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes. J Immunol. 1988 Sep 1;141(5):1652-7. [Content Brief]

[3]. Brulfert A, et al. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia. 1974 Sep 15;30(9):1010-1. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7418 mL	18.7091 mL	37.4181 mL	93.5454 mL
	5 mM	0.7484 mL	3.7418 mL	7.4836 mL	18.7091 mL
	10 mM	0.3742 mL	1.8709 mL	3.7418 mL	9.3545 mL
	15 mM	0.2495 mL	1.2473 mL	2.4945 mL	6.2364 mL
	20 mM	0.1871 mL	0.9355 mL	1.8709 mL	4.6773 mL
	25 mM	0.1497 mL	0.7484 mL	1.4967 mL	3.7418 mL
	30 mM	0.1247 mL	0.6236 mL	1.2473 mL	3.1182 mL
	40 mM	0.0935 mL	0.4677 mL	0.9355 mL	2.3386 mL
	50 mM	0.0748 mL	0.3742 mL	0.7484 mL	1.8709 mL
	60 mM	0.0624 mL	0.3118 mL	0.6236 mL	1.5591 mL
	80 mM	0.0468 mL	0.2339 mL	0.4677 mL	1.1693 mL
	100 mM	0.0374 mL	0.1871 mL	0.3742 mL	0.9355 mL

2'-Deoxyguanosine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyguanosine961-07-9Deoxyguanosine Guanine deoxyribosideEndogenous MetaboliteHL-60K562Mouse thymus cellsCell divisionInhibitorinhibitorinhibit

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2'-Deoxyguanosine (Synonyms: Deoxyguanosine; Guanine deoxyriboside)

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Other Forms of 2'-Deoxyguanosine:

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

2'-Deoxyguanosine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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2'-Deoxyguanosine (Synonyms: Deoxyguanosine; Guanine deoxyriboside)

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Other Forms of 2'-Deoxyguanosine:

2'-Deoxyguanosine 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

2'-Deoxyguanosine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

2'-Deoxyguanosine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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Request for HNMR Report

Request for HNMR Report