Leukotriene B4  (Synonyms: LTB4; 5(S),12(R)-DiHETE)

Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1][2][3].

Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation^[2].
Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

336.47

C₂₀H₃₂O₄

71160-24-2

Liquid

Colorless to light yellow

CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562  [Content Brief]

  [2]. S.WCrooks, et al. Leukotriene B4. The International Journal of Biochemistry & Cell Biology Volume 30, Issue 2, 27 March 1998, Pages 173-178.

  [3]. Takehiko Yokomizo, et al. Leukotriene B4: Metabolism and Signal Transduction. Archives of Biochemistry and Biophysics Volume 385, Issue 2, 15 January 2001, Pages 231-241.