2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cytosine

Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Cytosine can be used in cancer research.

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Cytosine

Cytosine 화학구조

CAS No. : 71-30-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
500 mg 해외재고보유
5 g 해외재고보유
10 g 해외재고보유
25 g 해외재고보유
50 g 해외재고보유
100 g 해외재고보유
250 g 해외재고보유
500 g 해외재고보유
1000 g 해외재고보유
> 100 g   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Cytosine:

Cytosine Related Antibodies

Top Publications Citing Use of Products

View All Endogenous Metabolite Isoform Specific Products:

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Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Cytosine can be used in cancer research[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Cytosine modifications change the accessibility of nucleosomal DNA through their effects on DNA flexibility[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cytosine Related Antibodies
Clinical Trial
분자량

111.10

화학식

C4H5N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC=CC(N)=N1
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

RT, protect from light

In solvent -80°C 1 year
-20°C 6 months
용액&용해도
In Vitro: 

DMSO : 10 mg/mL (90.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.0006 mL 45.0029 mL 90.0058 mL
5 mM 1.8001 mL 9.0006 mL 18.0012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (9.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (9.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.99%

SDS (393 KB)

COA (249 KB) HNMR (117 KB) RP-HPLC (223 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.0006 mL 45.0029 mL 90.0058 mL 225.0144 mL
5 mM 1.8001 mL 9.0006 mL 18.0012 mL 45.0029 mL
10 mM 0.9001 mL 4.5003 mL 9.0006 mL 22.5014 mL
15 mM 0.6000 mL 3.0002 mL 6.0004 mL 15.0010 mL
20 mM 0.4500 mL 2.2501 mL 4.5003 mL 11.2507 mL
25 mM 0.3600 mL 1.8001 mL 3.6002 mL 9.0006 mL
30 mM 0.3000 mL 1.5001 mL 3.0002 mL 7.5005 mL
40 mM 0.2250 mL 1.1251 mL 2.2501 mL 5.6254 mL
50 mM 0.1800 mL 0.9001 mL 1.8001 mL 4.5003 mL
60 mM 0.1500 mL 0.7500 mL 1.5001 mL 3.7502 mL
80 mM 0.1125 mL 0.5625 mL 1.1251 mL 2.8127 mL
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Cytosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytosine71-30-7Endogenous MetaboliteCircadian oscillationsEpigenetic diversity.Inhibitorinhibitorinhibit

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상품명:
Cytosine
Cat. No.:
HY-I0626
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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