2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 7-Dehydrocholesterol

7-デヒドロコレステロール  (Synonyms: 7-Dehydrocholesterol)

製品番号: HY-113279 純度: 99.97%
COA 取扱説明書 Technical Support

7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

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CAS 番号 : 434-16-2

容量 価格（税別） 在庫状況 数量
Solution
10 mM * 1 mL in Ethanol USD 66 在庫あり
Solid
100 mg $60 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of 7-Dehydrocholesterol:

7-デヒドロコレステロール 関連抗体

Top Publications Citing Use of Products

    7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2025 Nov 29:794:153070.  [Abstract]

    Cell viability of MuSCs with different concentrations of 7-Dehydrocholesterol (7-DHC).

    7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2025 Nov 29:794:153070.  [Abstract]

    The protein level of CCL2 in MuSCs after pre-treatment of MuSCs with 7-Dehydrocholesterol (7-DHC) (in a co-culture system).

    7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6.  [Abstract]

    Mouse naive CD8+ T cells were transiently treated with 1 or 2 ng/μL 7-Dehydrocholesterol (7a-HC) in A and 2 ng/μL 7a-HC for 20 min.

    7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6.  [Abstract]

    Effects of transient 7-Dehydrocholesterol (7a-HC) treatment on the phosphorylation levels of TCR and downstream molecules in mouse T cells. Mouse naive CD4+ T cells were transiently treated with 2 ng/μL 7a-HC for 20 min and then stimulated with 5 ng/μL α-CD3ε and 5 ng/μL α-CD28.

    7-Dehydrocholesterol purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2024 May 16;31(5):920-931.e6.  [Abstract]

    Naïve mouse CD8+ T cells were treated with 10 ng/μL cholesterol, 2 ng/μL 7-Dehydrocholesterol (7a-HC) for 20 min, or without any treatment. The plasma membrane was then labeled with octadecylrhodamine B (R18).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    7-デヒドロコレステロール 関連抗体
    分子量

    384.64

    分子式

    C27H44O
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    Ethanol : 12.5 mg/mL (32.50 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5998 mL 12.9992 mL 25.9983 mL
    5 mM 0.5200 mL 2.5998 mL 5.1997 mL
    10 mM 0.2600 mL 1.2999 mL 2.5998 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.97%

    COA (248 KB) HNMR (262 KB) RP-HPLC (206 KB) MS (82 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 2.5998 mL 12.9992 mL 25.9983 mL 64.9958 mL
    5 mM 0.5200 mL 2.5998 mL 5.1997 mL 12.9992 mL
    10 mM 0.2600 mL 1.2999 mL 2.5998 mL 6.4996 mL
    15 mM 0.1733 mL 0.8666 mL 1.7332 mL 4.3331 mL
    20 mM 0.1300 mL 0.6500 mL 1.2999 mL 3.2498 mL
    25 mM 0.1040 mL 0.5200 mL 1.0399 mL 2.5998 mL
    30 mM 0.0867 mL 0.4333 mL 0.8666 mL 2.1665 mL
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    • Your name will appear on the site.

    7-Dehydrocholesterol Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    7-Dehydrocholesterol434-16-2Endogenous MetaboliteInhibitorinhibitorinhibit

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    製品名:
    7-Dehydrocholesterol
    製品番号:
    HY-113279
    数量:
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