2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
  4. Citraconic acid

シトラコン酸  (Synonyms: Methylmaleic acid; Citraconic acid)

製品番号: HY-113298 純度: 99.08%
COA 取扱説明書 Technical Support

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052).

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Citraconic acid

シトラコン酸 構造式

CAS 番号 : 498-23-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
500 mg $50 在庫あり
5 g $60 在庫あり
10 g $78 在庫あり
25 g $120 在庫あり
50 g $150 在庫あり
> 100 g   お問い合わせ  

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Based on 4 publication(s) in Google Scholar

Other Forms of Citraconic acid:

シトラコン酸 関連抗体

Top Publications Citing Use of Products

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NLRP3 NLRP1 NOD1 NOD2

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製品説明

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052)[1][2][3].

IC50 & Target

NLRP3

 

体外実験

Hydrogel preparation and enzyme immobilization experiments:
Citraconic acid (molar ratio of acrylamide to 1:3; polymerization reaction time 24 h) can be used to prepare chitosan-polyacrylamide-citraconic acid semi-IPN hydrogels and significantly improve the hydrogel swelling rate (240%-400%). The yield of lipase immobilization in the encapsulation method is high[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

シトラコン酸 関連抗体
体内実験

Citraconic acid (50 mg/kg; intraperitoneal injection; once a day; 3 days) significantly reduces the levels of serum creatinine (Cr), urea (Urea) and cystatin C (Cys-C) in the rat renal ischemia-reperfusion injury model, alleviates renal tubular epithelial cell damage, inflammatory cell infiltration and oxidative stress, and inhibits NLRP3 inflammasome activation and IL-1β and IL-18 release[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat renal ischemia-reperfusion injury model (250-300 g，8-10 weeks old)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, once daily for 3 consecutive days, starting 3 days before ischemia-reperfusion surgery
Result: Significantly improved renal function compared to the ischemia-reperfusion (IRI) group.
Decreased Serum Cr from 1.82 ± 0.23 mg/dL (IRI) to 1.25 ± 0.18 mg/dL, urea from 72.3 mg/dL to 51.6 mg/dL, and Cys-C from 1.57 ± 0.19.
分子量

130.10

分子式

C5H6O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C(C)=C\C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (768.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (768.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6864 mL 38.4320 mL 76.8639 mL
5 mM 1.5373 mL 7.6864 mL 15.3728 mL
10 mM 0.7686 mL 3.8432 mL 7.6864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (19.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (19.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.08%

COA (247 KB) HNMR (259 KB) LCMS (87 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.6864 mL 38.4320 mL 76.8639 mL 192.1599 mL
5 mM 1.5373 mL 7.6864 mL 15.3728 mL 38.4320 mL
10 mM 0.7686 mL 3.8432 mL 7.6864 mL 19.2160 mL
15 mM 0.5124 mL 2.5621 mL 5.1243 mL 12.8107 mL
20 mM 0.3843 mL 1.9216 mL 3.8432 mL 9.6080 mL
25 mM 0.3075 mL 1.5373 mL 3.0746 mL 7.6864 mL
30 mM 0.2562 mL 1.2811 mL 2.5621 mL 6.4053 mL
40 mM 0.1922 mL 0.9608 mL 1.9216 mL 4.8040 mL
50 mM 0.1537 mL 0.7686 mL 1.5373 mL 3.8432 mL
60 mM 0.1281 mL 0.6405 mL 1.2811 mL 3.2027 mL
80 mM 0.0961 mL 0.4804 mL 0.9608 mL 2.4020 mL
100 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9216 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Citraconic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Citraconic acid498-23-7Methylmaleic acidNOD-like Receptor (NLR)Keap1-Nrf2Reactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

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