2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Endogenous Metabolite Glycosidase Monoamine Oxidase
  4. D-(-)-Quinic acid

D-(-)-Quinic acid  (Synonyms: D-(?)-キナ酸)

製品番号: HY-N0464 純度: 98.0%
COA 取扱説明書 Technical Support

D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active.

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D-(-)-Quinic acid

D-(-)-Quinic acid 構造式

CAS 番号 : 77-95-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in Water USD 44 在庫あり
Solid
100 mg $40 在庫あり
500 mg $80 在庫あり
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Based on 3 publication(s) in Google Scholar

Other Forms of D-(-)-Quinic acid:

D-(-)-Quinic acid 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

Monoamine Oxidase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MAO-A MAO-B

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active[1][2].

IC50 & Target

Microbial Metabolite

 

Cellular Effect
Cell Line Type Value Description References
MT2 ED50
>1823 3
Compound: quinic acid
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
[PMID: 9986720]
MT2 ED50
> 1823 3
Compound: quinic acid
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
[PMID: 9986720]
体内実験

D-(-)-Quinic acid (75-300 mg/kg, po, once daily for 49 days) exhibits lipid-lowering activity, improves obesity and fatty liver induced by high-fat diet in mouse models[1].
D-(-)-Quinic acid (200-400 mg/kg, po, once daily for 10 days) reduces the levels of AChE, malondialdehyde and nitrite, increases the expression of GSH, catalase and SOD in brain tissue, improves the cognitive dysfunction of rats in aluminum ion-induced dementia rat models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese mouse model induced by high-fat diet[1]
Dosage: 75-300 mg/kg
Administration: po, once daily for 49 days
Result: Reduced the body weight, liver weight, blood lipid levels, liver function indexes and inflammatory factor levels of obese mice. Improved liver tissue pathological changes.
Animal Model: Aluminum ion-induced dementia rat models[2]
Dosage: 200-400 mg/kg
Administration: po, once daily for 10 days
Result: Improved the escape latency (ELT) and target quadrant residence in morris water maze test.
Increased locomotor activity in actophotometer test.
Reduced neuronal degeneration and preserved normal tissue structure in hippocampus and cortex.
分子量

192.17

分子式

C7H12O6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]1(O)C[C@@H](O)[C@@H](O)[C@H](O)C1)O
Structure Classification
Initial Source

Widespread
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 116.67 mg/mL (607.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2038 mL 26.0190 mL 52.0381 mL
5 mM 1.0408 mL 5.2038 mL 10.4076 mL
10 mM 0.5204 mL 2.6019 mL 5.2038 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (520.38 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 98.0%

COA (253 KB) HNMR (256 KB) LCMS (88 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2038 mL 26.0190 mL 52.0381 mL 130.0952 mL
5 mM 1.0408 mL 5.2038 mL 10.4076 mL 26.0190 mL
10 mM 0.5204 mL 2.6019 mL 5.2038 mL 13.0095 mL
15 mM 0.3469 mL 1.7346 mL 3.4692 mL 8.6730 mL
20 mM 0.2602 mL 1.3010 mL 2.6019 mL 6.5048 mL
25 mM 0.2082 mL 1.0408 mL 2.0815 mL 5.2038 mL
30 mM 0.1735 mL 0.8673 mL 1.7346 mL 4.3365 mL
40 mM 0.1301 mL 0.6505 mL 1.3010 mL 3.2524 mL
50 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6019 mL
60 mM 0.0867 mL 0.4337 mL 0.8673 mL 2.1683 mL
80 mM 0.0650 mL 0.3252 mL 0.6505 mL 1.6262 mL
100 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3010 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-(-)-Quinic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-(-)-Quinic acid77-95-2Endogenous MetaboliteGlycosidaseMonoamine OxidaseMAOlipid-loweringdementiaantioxidantorally activeInhibitorinhibitorinhibit

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