Desmosterol  (Synonyms: デスモステロール)

Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism ^[1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases ^[1][2][3].

Desmosterol depletion (by activating the DHCR24 gene in Dhcr24TG mice to lower Desmosterol levels in macrophages for 4 weeks) inhibits LXR activation, upregulates immune response genes, suppresses cholesterol efflux, thereby leading to lipid accumulation in macrophages and foam cell formation, which is closely associated with the development of atherosclerosis disease ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Desmosterol depletion (by intraperitoneal injection of Adenovirus (AAV-Cre) to activate the DHCR24 gene in Dhcr24TG mice, thereby reducing Desmosterol levels in macrophages) would suppress LXR activation, upregulate immune response genes, inhibit cholesterol efflux, leading to lipid accumulation in macrophages and foam cell formation, which is closely associated with the development of atherosclerosis disease ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

384.64

C27H44O

313-04-2

Solid

White to off-white

C/C(C)=C\CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18(3):264-266.  [Content Brief]

  [2]. Zhang X, et al. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2107682118.  [Content Brief]

  [3]. Muse ED, et al. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689.  [Content Brief]