Diloxanide furoate

Name: Diloxanide furoate
Brand: MedChemExpress
SKU: HY-B1147
Rating: 4.5 (1 reviews)

製品番号: HY-B1147 純度: 99.39%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Diloxanide furoate 構造式

CAS 番号 : 3736-81-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid
10 mg	$50	在庫あり	Estimated Time of Arrival: December 31
25 mg	$100	在庫あり	Estimated Time of Arrival: December 31
50 mg	$160	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Diloxanide furoate:

Diloxanide furoate (Standard) お問い合わせ

顧客検証

•Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]

Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Amebae

体外実験

Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED₅₀ value is 77.9 mg/kg for this agent in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Weanling Wistar rats^[2]
Dosage:	200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg
Administration:	Oral administraion; 75-200 mg/kg; 3 days; once daily
Result:	Was against intestinal (caecal) amoebiasis in rats.

分子量

328.15

分子式

C₁₄H₁₁Cl₂NO₄

CAS 番号

3736-81-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CO1)OC2=CC=C(N(C(C(Cl)Cl)=O)C)C=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 50 mg/mL (152.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 20 mg/mL (60.95 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0474 mL	15.2369 mL	30.4739 mL
5 mM	0.6095 mL	3.0474 mL	6.0948 mL
10 mM	0.3047 mL	1.5237 mL	3.0474 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.80%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (247 KB) LCMS (121 KB)

取扱説明書 (2659 KB)

参考文献

[1]. VA CLASSIFICATION. Diloxanide (Systemic)

[2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	3.0474 mL	15.2369 mL	30.4739 mL	76.1847 mL
	5 mM	0.6095 mL	3.0474 mL	6.0948 mL	15.2369 mL
	10 mM	0.3047 mL	1.5237 mL	3.0474 mL	7.6185 mL
	15 mM	0.2032 mL	1.0158 mL	2.0316 mL	5.0790 mL
	20 mM	0.1524 mL	0.7618 mL	1.5237 mL	3.8092 mL
	25 mM	0.1219 mL	0.6095 mL	1.2190 mL	3.0474 mL
	30 mM	0.1016 mL	0.5079 mL	1.0158 mL	2.5395 mL
	40 mM	0.0762 mL	0.3809 mL	0.7618 mL	1.9046 mL
	50 mM	0.0609 mL	0.3047 mL	0.6095 mL	1.5237 mL
	60 mM	0.0508 mL	0.2539 mL	0.5079 mL	1.2697 mL
DMSO	80 mM	0.0381 mL	0.1905 mL	0.3809 mL	0.9523 mL
DMSO	100 mM	0.0305 mL	0.1524 mL	0.3047 mL	0.7618 mL