ジオスシン  (Synonyms: Dioscin; Collettiside III; CCRIS 4123)

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity^{[1][2][3][4][5][6]}.

Dioscin (1.25-5 μg/mL; 6-24 h) increases intracellular calcium levels and induces apoptosis in HeLa and SiHa cells^[4].
Dioscin (1.25-5 μg/mL; 6-24 h) Dioscin up-regulates the protein levels of Bak, Bax, Bid, p53, caspase-3, caspase-9, and down-regulates the proteins of Bcl-2 and Bcl-xl level^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dioscin (75-300 mg/kg, 10 mL/kg; oral gavage; 90 days) has no subchronic toxicity in female rats and mild subchronic toxicity in male rats. Dioscin caused mild gastrointestinal dilatation in male rats and demonstrated hemolytic anemia on hematological evaluation^[5].
Dioscin can reduce liver ischemia-reperfusion injury in rats by inhibiting oxidative-nitrative stress, inflammation and apoptosis^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

869.04

C₄₅H₇₂O₁₆

19057-60-4

Solid

White to off-white

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Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.  [Content Brief]

  [2]. Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.  [Content Brief]

  [3]. Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.  [Content Brief]

  [4]. Zhao X, et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016 Jun 4;21(6):730.  [Content Brief]

  [5]. Xu T, et al. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats. Food Chem Toxicol. 2012 May;50(5):1279-87.  [Content Brief]

  [6]. Tao X, et al. Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. Transplantation. 2014 Sep 27;98(6):604-11.  [Content Brief]