2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics
  3. ATP Citrate Lyase AMPK
  4. Bempedoic acid

Bempedoic acid  (Synonyms: ETC-1002; ESP-55016)

製品番号: HY-12357 純度: 99.88%
COA 取扱説明書 Technical Support

Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK.

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CAS 番号 : 738606-46-7

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 67 在庫あり
Solution
10 mM * 1 mL in DMSO USD 67 在庫あり
Solid
5 mg $61 在庫あり
10 mg $88 在庫あり
25 mg $172 在庫あり
50 mg $297 在庫あり
100 mg $495 在庫あり
250 mg $840 在庫あり
500 mg $1260 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 22 publication(s) in Google Scholar

Other Forms of Bempedoic acid:

Bempedoic acid 関連抗体

Top Publications Citing Use of Products

    Bempedoic acid purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Jan 30:184:117876.  [Abstract]

    Bempedoic acid (BemA) (30 mg/kg, i.g.) attenuated the compensatory increase in aortic collagen I expression and decreased the enhanced vascular expression of Mmp-2 induced by Ang II and lowered Mmp-9 mRNA levels compared with mice receiving Ang II alone.

    Bempedoic acid purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):239-254.e7.  [Abstract]

    Bempedoic acid (BPA) (30 mg/kg, i.g.) yielded a significant reduction in total DNL in mice consuming sweetened water.

    Bempedoic acid purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):239-254.e7.  [Abstract]

    Bempedoic acid (BPA) (30 mg/kg, i.g.) also promoted ACSS2 upregulation and increases in pAMPK by western blot.

    Bempedoic acid purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):239-254.e7.  [Abstract]

    Treatment with Bempedoic acid (BPA) (30 mg/kg, i.g.) abrogated the genotype-dependent difference in liver weight and dramatically suppressed steatosis in both WT and LAKO mice.

    Bempedoic acid purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):239-254.e7.  [Abstract]

    Treatment with Bempedoic acid (BPA) (30 mg/kg, i.g.) abrogated the genotype-dependent difference in liver weight and dramatically suppressed steatosis in both WT and LAKO mice.

    AMPK アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

    IC50 & Target[1]

    AMPK

     

    体外実験

    Bempedoic acid (ETC-1002) activates AMP-activated protein kinase in a Ca2+/calmodulin-dependent kinase β-independent and liver kinase β 1-dependent manner, without detectable changes in adenylate energy charge. Bempedoic acid is shown to rapidly form a CoA thioester in liver, which directly inhibits ATP-citrate lyase[1]. In cells treated with Bempedoic acid (ETC-1002), increased levels of AMP-activated protein kinase (AMPK) phosphorylation coincide with reduced activity of MAP kinases and decreased production of proinflammatory cytokines and chemokines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bempedoic acid 関連抗体
    体内実験

    A marked and sustained increase in AMPK and ACC phosphorylation is found in rat livers following two weeks of treatment with Bempedoic acid (ETC-1002). Bempedoic acid is >100-fold more prevalent than the CoA thioester in rat liver and is associated with AMPK activation[1]. Bempedoic acid (ETC-1002) suppresses thioglycollate-induced homing of leukocytes into mouse peritoneal cavity. In a mouse model of diet-induced obesity, Bempedoic acid restores adipose AMPK activity, reduces JNK phosphorylation, and diminishes expression of macrophage-specific marker 4F/80[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    344.49

    分子式

    C19H36O5
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C(O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (290.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9028 mL 14.5142 mL 29.0284 mL
    5 mM 0.5806 mL 2.9028 mL 5.8057 mL
    10 mM 0.2903 mL 1.4514 mL 2.9028 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 2.87 mg/mL (8.33 mM); Clear solution

    • Protocol 2

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: 2.87 mg/mL (8.33 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.88%

    COA (240 KB) HNMR (253 KB) RP-HPLC (245 KB)

    取扱説明書 (2659 KB)
    参考文献
    細胞実験
    [1]

    Glucose production is measured in primary rat hepatocyte cultures. Cells are cultured in glucose- and phenol red-free DMEM, containing 10 mM lactate, 1 mM pyruvate, and nonessential amino acids. Cells are incubated with various concentrations of Bempedoic acid (0.1 to 100 μM)[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    動物実験
    [1]

    Rats: Prior to single-dose Bempedoic acid administration, Male Wistar Han rats are fasted for 48 h and refed a high-carbohydrate diet for an additional 48 h. For two-week assessment, rats are maintained on standard chow diet and dosed by oral gavage with Bempedoic acid at 30 mg/kg/day for two weeks in the morning. Following nutritional staging and/or dosing, food is withdrawn 2 h prior to last the oral dose of ehicle control or Bempedoic acid[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9028 mL 14.5142 mL 29.0284 mL 72.5710 mL
    5 mM 0.5806 mL 2.9028 mL 5.8057 mL 14.5142 mL
    10 mM 0.2903 mL 1.4514 mL 2.9028 mL 7.2571 mL
    15 mM 0.1935 mL 0.9676 mL 1.9352 mL 4.8381 mL
    20 mM 0.1451 mL 0.7257 mL 1.4514 mL 3.6286 mL
    25 mM 0.1161 mL 0.5806 mL 1.1611 mL 2.9028 mL
    30 mM 0.0968 mL 0.4838 mL 0.9676 mL 2.4190 mL
    40 mM 0.0726 mL 0.3629 mL 0.7257 mL 1.8143 mL
    50 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4514 mL
    60 mM 0.0484 mL 0.2419 mL 0.4838 mL 1.2095 mL
    80 mM 0.0363 mL 0.1814 mL 0.3629 mL 0.9071 mL
    100 mM 0.0290 mL 0.1451 mL 0.2903 mL 0.7257 mL
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    Bempedoic acid Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bempedoic acid738606-46-7ETC-1002 ESP-55016ETC1002ETC 1002ESP55016ESP 55016ESP-55016ATP Citrate LyaseAMPKACLYAMP-activated protein kinaseInhibitorinhibitorinhibit

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