2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Flavin adenine dinucleotide

Flavin adenine dinucleotide  (Synonyms: FAD)

製品番号: HY-B1654 純度: 98.93%
COA 取扱説明書 Technical Support

Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

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CAS 番号 : 146-14-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 86 在庫あり
Solution
10 mM * 1 mL in Water USD 86 在庫あり
Solid
5 mg $50 在庫あり
10 mg $70 在庫あり
25 mg $118 在庫あり
50 mg $170 在庫あり
100 mg $250 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Flavin adenine dinucleotide:

Flavin adenine dinucleotide 関連抗体

Top Publications Citing Use of Products

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Hep3B and HCCLM3 cells treated with Riboflavin (VB2; 10 µM), Riboflavin phosphate sodium (FMN; 10 µM), Flavin adenine dinucleotide (FAD; 10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Relative mRNA levels of interferon-stimulated genes (ISG15, IFIT1, IFNB1) and chemokines (CCL5, CXCL9, CXCL10) in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h; H-151 (STING inhibitor), 1 μM for 12 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Levels of ROS and lipid peroxidation in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    GR activity, GSH levels, and GSH/GSSG ratio in Hep3B cells (n = 4 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Hep3B cells with FADS-knockdown treated with VB2 (10 µM), FMN (10 µM), Flavin adenine dinucleotide (FAD;10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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    製品説明

    Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    体外実験

    Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Flavin adenine dinucleotide 関連抗体
    体内実験

    Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    785.55

    分子式

    C27H33N9O15P2
    CAS 番号
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)CN4C(C(C(N5)=O)=NC6=C4C=C(C)C(C)=C6)=NC5=O)(O)=O)(O)=O)O3
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL (127.30 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2730 mL 6.3650 mL 12.7299 mL
    5 mM 0.2546 mL 1.2730 mL 2.5460 mL
    10 mM 0.1273 mL 0.6365 mL 1.2730 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.93%

    COA (257 KB) HNMR (303 KB) CNMR (268 KB) RP-HPLC (261 KB) MS (70 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [1]

    Dogs[1]
    The dogs are divided into 3 groups and they are received the following treatments. Each group consists of 6 dogs. Dogs in group I as control, are given 2 mL/kg of physiological saline by intravenous injection. Ten min after the start of the first injection, another dose of saline, 1 mL/kg, is injected intravenously. Dogs in group II are given i.v. 2 mL saline/kg. Ten min afterwards, 1 mg chlorpromazine(CPZ)/kg is injected. Dogs in group III are given i.v. Flavin Adenin Dinucleotide, 2 mg/kg. Ten min later, they are given CPZ, 1 mg/kg. All solutions is administrated in 1 min or 2. Blood samples are taken before and 10, 20, 30, and 40 min after the intravenous injection of saline (groups I and II) or Flavin Adenin Dinucleotide (group III). Serum K+ and blood pH are also measured. Heart rate, blood pressure and ventricular fibrillation threshold (VFT) of each dog are recorded at the same intervals[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.2730 mL 6.3650 mL 12.7299 mL 31.8248 mL
    5 mM 0.2546 mL 1.2730 mL 2.5460 mL 6.3650 mL
    10 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1825 mL
    15 mM 0.0849 mL 0.4243 mL 0.8487 mL 2.1217 mL
    20 mM 0.0636 mL 0.3182 mL 0.6365 mL 1.5912 mL
    25 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2730 mL
    30 mM 0.0424 mL 0.2122 mL 0.4243 mL 1.0608 mL
    40 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7956 mL
    50 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6365 mL
    60 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
    80 mM 0.0159 mL 0.0796 mL 0.1591 mL 0.3978 mL
    100 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Flavin adenine dinucleotide Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Flavin adenine dinucleotide146-14-5FADEndogenous MetaboliteInhibitorinhibitorinhibit

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    製品名:
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