Cat. No.: HY-B1654A

Flavin adenine dinucleotide disodium salt

(Synonyms: FAD disodium salt; FAD-Na2)

9 Cited Publications

Avis client

Based on 9 publication(s) in Google Scholar

Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.72%
CAS No.: 84366-81-4
Formule: C₂₇H₃₁N₉Na₂O₁₅P₂
Masse moléculaire:829.51

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Flavin adenine dinucleotide disodium salt Chemical Structure

CAS No.: 84366-81-4

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (9)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

In Vitro

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10^-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 84366-81-4
Appearance Solid
Masse moléculaire 829.51
Formule C₂₇H₃₁N₉Na₂O₁₅P₂
Color Yellow to orange
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)CN4C(C(C(N5)=O)=NC6=C4C=C(C)C(C)=C6)=NC5=O)(O[Na])=O)(O[Na])=O)O3
Synonyms

FAD disodium salt; FAD-Na2
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (9)

All Cell Proliferation/Viability AssayRT-PCRBio/Physico-chemical AssayWB

Sort by:

Journal Impact Factor

Cell Metab

Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy. [Abstract]

2026 Mar 3;38(3):565-581.e5. PMID: 41570815
Cancer Res

TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Jul 15;86(14):3436-3458. PMID: 41974002
Nat Commun

FAD synthase confers ferroptosis resistance and restrains CD8+ T cell recruitment in hepatocellular carcinoma. [Abstract]

2025 Oct 29;16(1):9547. PMID: 41162372

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547. [Abstract]

Hep3B and HCCLM3 cells treated with Riboflavin (VB2; 10 µM), Riboflavin phosphate sodium (FMN; 10 µM), Flavin adenine dinucleotide (FAD; 10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547. [Abstract]

Relative mRNA levels of interferon-stimulated genes (ISG15, IFIT1, IFNB1) and chemokines (CCL5, CXCL9, CXCL10) in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h; H-151 (STING inhibitor), 1 μM for 12 h.

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547. [Abstract]

Levels of ROS and lipid peroxidation in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547. [Abstract]

GR activity, GSH levels, and GSH/GSSG ratio in Hep3B cells (n = 4 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547. [Abstract]

Hep3B cells with FADS-knockdown treated with VB2 (10 µM), FMN (10 µM), Flavin adenine dinucleotide (FAD;10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.
Nat Commun

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation. [Abstract]

2025 Jan 2;16(1):212. PMID: 39747079

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):212. [Abstract]

H1299-shMT-CO2 cells were treated with 20 μM Flavin adenine dinucleotide disodium salt (FAD) for 48 h, followed by CHIP-qPCR analyses (n = 3 independent experiments).

Flavin adenine dinucleotide disodium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):212. [Abstract]

H1299 cells were treated with an indicated concentration of Flavin adenine dinucleotide disodium salt (FAD) for 48 h, followed by western blot analyses.
J Med Chem

Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis. [Abstract]

2024 Nov 14;67(21):19874-19888. PMID: 39499621
Microb Biotechnol

Novel Anthraquinone Chlorination Contributes to Pigmentation and ATP Formation in Thermomyces dupontii. [Abstract]

2025 Oct;18(10):e70254. PMID: 41123250
Int J Mol Sci

Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]

2025 Feb 6;26(3):1381. PMID: 39941149
Res Sq

2025 Oct 3.
SSRN

2025 Sep 11.

Solvant et solubilité

In Vitro:

H₂O : 33.33 mg/mL (40.18 mM; Need ultrasonic)

DMSO : 5 mg/mL (6.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2055 mL

6.0277 mL

12.0553 mL

5 mM

0.2411 mL

1.2055 mL

2.4111 mL

10 mM

0.1206 mL

0.6028 mL

1.2055 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65. [Content Brief]

[2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	1.2055 mL	6.0277 mL	12.0553 mL	30.1383 mL
DMSO / H₂O	5 mM	0.2411 mL	1.2055 mL	2.4111 mL	6.0277 mL
H₂O	10 mM	0.1206 mL	0.6028 mL	1.2055 mL	3.0138 mL
	15 mM	0.0804 mL	0.4018 mL	0.8037 mL	2.0092 mL
	20 mM	0.0603 mL	0.3014 mL	0.6028 mL	1.5069 mL
	25 mM	0.0482 mL	0.2411 mL	0.4822 mL	1.2055 mL
	30 mM	0.0402 mL	0.2009 mL	0.4018 mL	1.0046 mL
	40 mM	0.0301 mL	0.1507 mL	0.3014 mL	0.7535 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Flavin adenine dinucleotide disodium salt

9 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Flavin adenine dinucleotide disodium salt

NADH disodium salt

Riboflavin phosphate sodium

NADPH tetrasodium salt

Diquafosol tetrasodium

NADPH

Riboflavin