2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Flavin adenine dinucleotide

Flavin adenine dinucleotide  (Synonyms: FAD)

Cat. No.: HY-B1654 Purity: 99.13%
COA Handling Instructions

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Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

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Flavin adenine dinucleotide Chemical Structure

Flavin adenine dinucleotide Chemical Structure

CAS No. : 146-14-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Flavin adenine dinucleotide:

Flavin adenine dinucleotide Related Antibodies

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Description

Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flavin adenine dinucleotide Related Antibodies
In Vivo

Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

785.55

Formula

C27H33N9O15P2
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

CC1=CC(N=C2C(N3)=O)=C(C=C1C)N(C[C@@H]([C@@H]([C@@H](COP(O)(OP(O)(OC[C@H]4O[C@@H](N5C=NC6=C(N=CN=C56)N)[C@@H]([C@@H]4O)O)=O)=O)O)O)O)C2=NC3=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (159.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2730 mL 6.3650 mL 12.7299 mL
5 mM 0.2546 mL 1.2730 mL 2.5460 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.13%

COA (257 KB) HNMR (295 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Dogs[1]
The dogs are divided into 3 groups and they are received the following treatments. Each group consists of 6 dogs. Dogs in group I as control, are given 2 mL/kg of physiological saline by intravenous injection. Ten min after the start of the first injection, another dose of saline, 1 mL/kg, is injected intravenously. Dogs in group II are given i.v. 2 mL saline/kg. Ten min afterwards, 1 mg chlorpromazine(CPZ)/kg is injected. Dogs in group III are given i.v. Flavin Adenin Dinucleotide, 2 mg/kg. Ten min later, they are given CPZ, 1 mg/kg. All solutions is administrated in 1 min or 2. Blood samples are taken before and 10, 20, 30, and 40 min after the intravenous injection of saline (groups I and II) or Flavin Adenin Dinucleotide (group III). Serum K+ and blood pH are also measured. Heart rate, blood pressure and ventricular fibrillation threshold (VFT) of each dog are recorded at the same intervals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2730 mL 6.3650 mL 12.7299 mL 31.8248 mL
5 mM 0.2546 mL 1.2730 mL 2.5460 mL 6.3650 mL
10 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1825 mL
15 mM 0.0849 mL 0.4243 mL 0.8487 mL 2.1217 mL
20 mM 0.0636 mL 0.3182 mL 0.6365 mL 1.5912 mL
25 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2730 mL
30 mM 0.0424 mL 0.2122 mL 0.4243 mL 1.0608 mL
40 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7956 mL
50 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6365 mL
60 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
80 mM 0.0159 mL 0.0796 mL 0.1591 mL 0.3978 mL
100 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Flavin adenine dinucleotide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flavin adenine dinucleotide146-14-5FADEndogenous MetaboliteInhibitorinhibitorinhibit

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