1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Flavin Adenin Dinucleotide (Synonyms: Flavitan; NSC 112207)

Cat. No.: HY-B1654
Handling Instructions

Flavin Adenin Dinucleotide is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

For research use only. We do not sell to patients.

Flavin Adenin Dinucleotide Chemical Structure

Flavin Adenin Dinucleotide Chemical Structure

CAS No. : 146-14-5

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Other Forms of Flavin Adenin Dinucleotide:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Flavin Adenin Dinucleotide is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Poly(Flavin Adenin Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

In Vivo

Flavin Adenin Dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin Adenin Dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin Adenin Dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenin Dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2730 mL 6.3650 mL 12.7299 mL
5 mM 0.2546 mL 1.2730 mL 2.5460 mL
10 mM 0.1273 mL 0.6365 mL 1.2730 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Dogs[1]
The dogs are divided into 3 groups and they are received the following treatments. Each group consists of 6 dogs. Dogs in group I as control, are given 2 mL/kg of physiological saline by intravenous injection. Ten min after the start of the first injection, another dose of saline, 1 mL/kg, is injected intravenously. Dogs in group II are given i.v. 2 mL saline/kg. Ten min afterwards, 1 mg chlorpromazine(CPZ)/kg is injected. Dogs in group III are given i.v. Flavin Adenin Dinucleotide, 2 mg/kg. Ten min later, they are given CPZ, 1 mg/kg. All solutions is administrated in 1 min or 2. Blood samples are taken before and 10, 20, 30, and 40 min after the intravenous injection of saline (groups I and II) or Flavin Adenin Dinucleotide (group III). Serum K+ and blood pH are also measured. Heart rate, blood pressure and ventricular fibrillation threshold (VFT) of each dog are recorded at the same intervals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

785.55

Formula

C₂₇H₃₃N₉O₁₅P₂

CAS No.

146-14-5

SMILES

CC1=CC(N=C2C(N3)=O)=C(C=C1C)N(C[[email protected]@H]([[email protected]@H]([[email protected]@H](COP(O)(OP(O)(OC[[email protected]]4O[[email protected]@H](N5C=NC6=C(N=CN=C56)N)[[email protected]@H]([[email protected]@H]4O)O)=O)=O)O)O)O)C2=NC3=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Flavin Adenin Dinucleotide
Cat. No.:
HY-B1654
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Flavin Adenin Dinucleotide

Cat. No.: HY-B1654