2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Flavin adenine dinucleotide

Flavin adenine dinucleotide  (Synonyms: FAD)

Cat. No.: HY-B1654 Pureza: 98.93%
COA
SDS
Instrucciones de manejo Technical Support

Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 146-14-5

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 8 publication(s) in Google Scholar

Other Forms of Flavin adenine dinucleotide:

Flavin adenine dinucleotide Related Antibodies

Top Publications Citing Use of Products

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Hep3B and HCCLM3 cells treated with Riboflavin (VB2; 10 µM), Riboflavin phosphate sodium (FMN; 10 µM), Flavin adenine dinucleotide (FAD; 10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Relative mRNA levels of interferon-stimulated genes (ISG15, IFIT1, IFNB1) and chemokines (CCL5, CXCL9, CXCL10) in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h; H-151 (STING inhibitor), 1 μM for 12 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Levels of ROS and lipid peroxidation in Hep3B cells (n = 3 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    GR activity, GSH levels, and GSH/GSSG ratio in Hep3B cells (n = 4 biological replicates). Flavin adenine dinucleotide (FAD), 20 µM for 48 h.

    Flavin adenine dinucleotide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Oct 29;16(1):9547.  [Abstract]

    Hep3B cells with FADS-knockdown treated with VB2 (10 µM), FMN (10 µM), Flavin adenine dinucleotide (FAD;10 µM), or PBS (Ctrl) for 48 h, followed by CCK-8 assay.

    Ver todos los productos específicos de isoformas Endogenous Metabolite:

    Ver todas las isoformas
    Human Endogenous Metabolite Microbial Metabolite

    • Actividad biológica

    • Protocolo

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Flavin adenine dinucleotide Related Antibodies
    In Vivo

    Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Ensayo clínico
    Peso molecular

    785.55

    Fòrmula

    C27H33N9O15P2
    No. CAS
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)CN4C(C(C(N5)=O)=NC6=C4C=C(C)C(C)=C6)=NC5=O)(O)=O)(O)=O)O3
    Structure Classification
    Initial Source
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvente y solubilidad
    In Vitro: 

    H2O : ≥ 100 mg/mL (127.30 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2730 mL 6.3650 mL 12.7299 mL
    5 mM 0.2546 mL 1.2730 mL 2.5460 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación

    Purity: 98.93%

    SDS (393 KB)

    COA (257 KB) HNMR (303 KB) CNMR (268 KB) RP-HPLC (261 KB) MS (70 KB)

    Instrucciones de manejo (2659 KB)
    Referencias
    Administraciòn de animales
    [1]

    Dogs[1]
    The dogs are divided into 3 groups and they are received the following treatments. Each group consists of 6 dogs. Dogs in group I as control, are given 2 mL/kg of physiological saline by intravenous injection. Ten min after the start of the first injection, another dose of saline, 1 mL/kg, is injected intravenously. Dogs in group II are given i.v. 2 mL saline/kg. Ten min afterwards, 1 mg chlorpromazine(CPZ)/kg is injected. Dogs in group III are given i.v. Flavin Adenin Dinucleotide, 2 mg/kg. Ten min later, they are given CPZ, 1 mg/kg. All solutions is administrated in 1 min or 2. Blood samples are taken before and 10, 20, 30, and 40 min after the intravenous injection of saline (groups I and II) or Flavin Adenin Dinucleotide (group III). Serum K+ and blood pH are also measured. Heart rate, blood pressure and ventricular fibrillation threshold (VFT) of each dog are recorded at the same intervals[1].

    MCE no ha confirmado la precisión de estos métodos independientemente. Son solo para referencia.
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.2730 mL 6.3650 mL 12.7299 mL 31.8248 mL
    5 mM 0.2546 mL 1.2730 mL 2.5460 mL 6.3650 mL
    10 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1825 mL
    15 mM 0.0849 mL 0.4243 mL 0.8487 mL 2.1217 mL
    20 mM 0.0636 mL 0.3182 mL 0.6365 mL 1.5912 mL
    25 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2730 mL
    30 mM 0.0424 mL 0.2122 mL 0.4243 mL 1.0608 mL
    40 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7956 mL
    50 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6365 mL
    60 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
    80 mM 0.0159 mL 0.0796 mL 0.1591 mL 0.3978 mL
    100 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Flavin adenine dinucleotide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Flavin adenine dinucleotide146-14-5FADEndogenous MetaboliteInhibitorinhibitorinhibit

    Productos vistos recientemente:

    Consulta en línea

    Your information is safe with us. * Required Fields.

    Nombre del producto

    		  

    Requested Quantity *

    Nombre del solicitante *

    		 

    Saludo

    Direcciòn del E-mail *

    		 

    Número de teléfono *

    Department

    		 

    Nombre de la Organizaciòn *

    City

    Provincia

    Country or Region *

    		      

    Observaciones

    Consulta para venta a granel

    Inquiry Information

    Nombre del producto:
    Flavin adenine dinucleotide
    Cat. No.:
    HY-B1654
    Cantidad:
    MCE Japan Authorized Agent:

    Revisión del cliente

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Nombre del producto

    		  

    Lot #

    Nombre del solicitante *

    		 

    Direcciòn del E-mail *

    Número de teléfono

    		 

    Department *

    Nombre de la Organizaciòn *

    		 

    Country or Region *

    Observaciones

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.