2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Homatropine (methylbromide)

Homatropine (methylbromide)  (Synonyms: Homatropine methobromide)

Cat. No.: HY-B1388 Pureza: 98.0%
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Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

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Homatropine (methylbromide)

Homatropine (methylbromide) Estructura química

No. CAS : 80-49-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO En stock
Solid
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Other Forms of Homatropine (methylbromide):

Homatropine (methylbromide) Related Antibodies

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Descripciòn

Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

IC50 & Target

IC50: WKY-E (162.5 nM), SHR-E (170.4 nM)
In Vitro

Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Homatropine (methylbromide) Related Antibodies
In Vivo

Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

370.28

Fòrmula

C17H24BrNO3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

C[N+]1([C@@H]2C[C@@H](OC(C(O)C3=CC=CC=C3)=O)C[C@H]1CC2)C.[Br-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : ≥ 100 mg/mL (270.07 mM)

DMSO : ≥ 31 mg/mL (83.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7007 mL 13.5033 mL 27.0066 mL
5 mM 0.5401 mL 2.7007 mL 5.4013 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.7007 mL 13.5033 mL 27.0066 mL 67.5165 mL
5 mM 0.5401 mL 2.7007 mL 5.4013 mL 13.5033 mL
10 mM 0.2701 mL 1.3503 mL 2.7007 mL 6.7516 mL
15 mM 0.1800 mL 0.9002 mL 1.8004 mL 4.5011 mL
20 mM 0.1350 mL 0.6752 mL 1.3503 mL 3.3758 mL
25 mM 0.1080 mL 0.5401 mL 1.0803 mL 2.7007 mL
30 mM 0.0900 mL 0.4501 mL 0.9002 mL 2.2505 mL
40 mM 0.0675 mL 0.3376 mL 0.6752 mL 1.6879 mL
50 mM 0.0540 mL 0.2701 mL 0.5401 mL 1.3503 mL
60 mM 0.0450 mL 0.2251 mL 0.4501 mL 1.1253 mL
80 mM 0.0338 mL 0.1688 mL 0.3376 mL 0.8440 mL
H2O 100 mM 0.0270 mL 0.1350 mL 0.2701 mL 0.6752 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Homatropine (methylbromide) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homatropine (methylbromide)80-49-9Homatropine methobromidemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Nombre del producto:
Homatropine (methylbromide)
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HY-B1388
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