2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics Immunology/Inflammation NF-κB
  3. Glycosidase AMPK Reactive Oxygen Species (ROS)
  4. Miglitol

Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets.

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Miglitol

Miglitol Chemical Structure

CAS No. : 72432-03-2

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
500 mg En stock
1 g En stock
5 g En stock
10 g   Obtenir un devis  
50 g   Obtenir un devis  

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Based on 2 publication(s) in Google Scholar

Other Forms of Miglitol:

Miglitol Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
1 μM
Compound: 5
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
[PMID: 18595718]
In Vitro

Miglitol (100-500 μM, 24 h) reduces endothelial cell injury in response to H2O2, exists cytoprotective effects against oxidative stress by H2O2 in bEnd.3 cells[4].
Miglitol (100-500 μM, 0-15 min) activates AMPK and induces eNOS activity and NO production in endothelial cells[4].
Miglitol (100-500 μM, 24 h) inhibits VCAM-1 and ICAM-1 mRNA expression and improves endothelial function in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Miglitol Related Antibodies

Cell Viability Assay[4]

Cell Line: bEnd.3 cells
Concentration: 100-500 μM
Incubation Time: 24 h
Result: Attenuated the bEnd.3 cell injury in response to H2O2, decreased cellular ROS production, reduced DNA injury and the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP).

Western Blot Analysis[4]

Cell Line: bEnd.3 cells
Concentration: 100-500 μM
Incubation Time: 0-15 min
Result: Resulted in time-dependent activation of AMPK, increased Akt phosphorylation (Ser-473) and eNOS phosphorylation (Ser-1177) and activation.
In Vivo

Miglitol (800 ppm, mixed in the diet, daily for 65 weeks) delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets in Otsuka Long-Evans Tokushima Fatty (OLETF) rats[1].
Miglitol (40 mg, mixed in the diet, daily for 29 days) decreases the body weight level, the postprandial plasma glucose level, the levels of plasma glucose and glycoalbumin, and elevates the level of HDL-C in fatty rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OLETF rats[1]
Dosage: 800 ppm
Administration: mixed in the diet, daily for 65 weeks
Result: Significantly increased the ΔAUC0-3 h of plasma insulin, HbA1c concentrations and decreased the size of the fibrous area/islets in OLETF rats.
Animal Model: Fatty rats[2]
Dosage: 40 mg
Administration: mixed in the diet, daily for 29 days
Result: Insignificantly decreased the body weight level on days 15 and 29 and significantly decreased the postprandial plasma glucose level, the levels of plasma glucose and glycoalbumin, and elevated the level of HDL-C in fatty rats.
Essai clinique
Masse moléculaire

207.22

Formule

C8H17NO5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O[C@@H]1[C@@H](CO)N(CCO)C[C@H](O)[C@H]1O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

H2O : ≥ 200 mg/mL (965.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8258 mL 24.1289 mL 48.2579 mL
5 mM 0.9652 mL 4.8258 mL 9.6516 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (482.58 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: 98.0%

SDS (394 KB)

COA (249 KB) HNMR (134 KB) CNMR (124 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8258 mL 24.1289 mL 48.2579 mL 120.6447 mL
5 mM 0.9652 mL 4.8258 mL 9.6516 mL 24.1289 mL
10 mM 0.4826 mL 2.4129 mL 4.8258 mL 12.0645 mL
15 mM 0.3217 mL 1.6086 mL 3.2172 mL 8.0430 mL
20 mM 0.2413 mL 1.2064 mL 2.4129 mL 6.0322 mL
25 mM 0.1930 mL 0.9652 mL 1.9303 mL 4.8258 mL
30 mM 0.1609 mL 0.8043 mL 1.6086 mL 4.0215 mL
40 mM 0.1206 mL 0.6032 mL 1.2064 mL 3.0161 mL
50 mM 0.0965 mL 0.4826 mL 0.9652 mL 2.4129 mL
60 mM 0.0804 mL 0.4021 mL 0.8043 mL 2.0107 mL
80 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5081 mL
100 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2064 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Miglitol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Miglitol72432-03-2BAY1099 BAY-m1099BAY 1099BAY-1099GlycosidaseAMPKReactive Oxygen Species (ROS)AMP-activated protein kinaseorally activeglycoconjugatesα-glucosidasesOLETF ratsinsulin secretoryInhibitorinhibitorinhibit

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