1. MAPK/ERK Pathway
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. ERK
    STAT
  3. Mogrol

Mogrol 

Cat. No.: HY-N2312 Purity: 98.06%
Handling Instructions

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

For research use only. We do not sell to patients.

Mogrol Chemical Structure

Mogrol Chemical Structure

CAS No. : 88930-15-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 199 In-stock
Estimated Time of Arrival: December 31
1 mg USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
25 mg USD 640 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

IC50 & Target[1]

ERK1

 

ERK2

 

STAT3

 

In Vitro

Mogrol (0-250 µM) significantly and dose- and time-dependently inhibits K562 cell growth and increases the number of apoptotic cells. Mogrol (0, 10, 100, and 250 µM) induces G1 phase cell cycle arrest in K562 cells. Treatment with mogrol significantly decreases ERK phosphorylation as compared to control cells, whereas total ERK protein is not affected. Mogrol dose-dependently induces growth arrest in G0/G1 phase of the cell cycle. Mogrol significantly and dose-dependently enhances p21 protein expression in K562 cells[1]. Mogrol significantly represses the increase in cellular TG levels induced by differentiation stimuli, and suppresses TG accumulation at micromolar levels, with a statistically significant suppression observed above 10 μM. Mogrol suppresses adipogenesis in 3T3-L1 cells at concentrations that does not affect cell viability. Mogrol suppresses adipogenesis through at least two different mechanisms, increasing AMPK phosphorylation and repressing the activation of CREB[2].

Molecular Weight

476.73

Formula

C₃₀H₅₂O₄

CAS No.

88930-15-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (230.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0976 mL 10.4881 mL 20.9762 mL
5 mM 0.4195 mL 2.0976 mL 4.1952 mL
10 mM 0.2098 mL 1.0488 mL 2.0976 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (5.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Cell viability is determined with a MTT assay. Leukemia cells are plated in triplicate into a 96-well plate. After overnight incubation, they are treated with various concentrations of mogrol (0, 0.1, 1, 10, 100, 200 and 250 µM) for 24 h and 48 h. The percentage of viable cells is calculated as the ratio (A490) of treated cells over control cells. Triplicate experiments are performed.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.06%

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Keywords:

MogrolERKSTATExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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