2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Phosphorylethanolamine

Phosphorylethanolamine  (Synonyms: Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine)

Cat. No.: HY-N5034 Pureza: 99.90%
COA
SDS
Instrucciones de manejo Technical Support

Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases.

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Phosphorylethanolamine

Phosphorylethanolamine Estructura química

No. CAS : 1071-23-4

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
5 g En stock
10 g En stock
25 g En stock
50 g En stock
100 g En stock
> 100 g   Obtener un presupuesto  

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Revisión del cliente

Based on 4 publication(s) in Google Scholar

Other Forms of Phosphorylethanolamine:

Phosphorylethanolamine Related Antibodies

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Human Endogenous Metabolite Microbial Metabolite

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  • Referencias

  • Revisión del cliente

Descripciòn

Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases[1][2][3][4][5].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Phosphorylethanolamine (Monoaminoethyl phosphate) arrests A2058 cells at the G2/M phase of the cell cycle and inhibits their proliferation, migration, and adhesion capabilities[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phosphorylethanolamine Related Antibodies

Cell Viability Assay[2]

Cell Line: A2058 cells, B16F10 cells
Concentration: 4.69-300 mM
Incubation Time: 24 h
Result: Not only reduced viability but also blocked the capacity of A2058 cells of forming new clones.
Peso molecular

141.06

Fòrmula

C2H8NO4P
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

NCCOP(O)(O)=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

H2O : 125 mg/mL (886.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.0892 mL 35.4459 mL 70.8918 mL
5 mM 1.4178 mL 7.0892 mL 14.1784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (708.92 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.90%

SDS (476 KB)

COA (244 KB) HNMR (253 KB) RP-HPLC (193 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.0892 mL 35.4459 mL 70.8918 mL 177.2296 mL
5 mM 1.4178 mL 7.0892 mL 14.1784 mL 35.4459 mL
10 mM 0.7089 mL 3.5446 mL 7.0892 mL 17.7230 mL
15 mM 0.4726 mL 2.3631 mL 4.7261 mL 11.8153 mL
20 mM 0.3545 mL 1.7723 mL 3.5446 mL 8.8615 mL
25 mM 0.2836 mL 1.4178 mL 2.8357 mL 7.0892 mL
30 mM 0.2363 mL 1.1815 mL 2.3631 mL 5.9077 mL
40 mM 0.1772 mL 0.8861 mL 1.7723 mL 4.4307 mL
50 mM 0.1418 mL 0.7089 mL 1.4178 mL 3.5446 mL
60 mM 0.1182 mL 0.5908 mL 1.1815 mL 2.9538 mL
80 mM 0.0886 mL 0.4431 mL 0.8861 mL 2.2154 mL
100 mM 0.0709 mL 0.3545 mL 0.7089 mL 1.7723 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Phosphorylethanolamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphorylethanolamine1071-23-4Monoaminoethyl NSC 254167 O-PhosphoethanolamineNSC254167NSC 254167NSC-254167Endogenous MetabolitePEExtracranial tumorsMetabolismInhibitorinhibitorinhibit

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