2. Cytoskeleton
  3. Integrin
  4. RGD

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

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カスタムペプチド

CAS 番号 : 99896-85-2

容量 価格（税別） 在庫状況 数量
5 mg $70 在庫あり
10 mg $120 在庫あり
25 mg $240 在庫あり
50 mg $380 在庫あり
100 mg $580 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of RGD:

Arg-Gly-Asp 関連抗体

Top Publications Citing Use of Products

    RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    RGD (0.2 mg/mL) was used to immobilize RAW264.7 cells on the hydrogel and minimize cell leakage during operation.

    RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    With or without RGD (0.2 mg/mL) modification, the numbers of RAW264.7 cells in the medium before and after loading and the percentage of cells loaded into the iMASSAGE device were shown.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) significantly ameliorated the prostate volume and the prostate weight-to-body weight ratio of testosterone (TP)-induced BPH mice.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) strikingly increased global succinylation levels in testosterone (TP)-induced BPH mice.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) therapy significantly ameliorated prostate hyperplasia of testosterone (TP)-induced BPH mice, as evidenced by the absence of morphological abnormalities such as excessive proliferation in the glandular epithelium, focal intraluminal papillary folds, and secretion-filled distended ducts.

    Integrin アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

    IC50 & Target

    Integrin[1]
    Cellular Effect
    Cell Line Type Value Description References
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    体外実験

    RGD is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Arg-Gly-Asp 関連抗体
    分子量

    346.34

    分子式

    C12H22N6O6
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Arg-Gly-Asp
    Sequence Shortening

    RGD
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    polypeptide, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    H2O : 10 mg/mL (28.87 mM; Need ultrasonic)

    DMSO : 1.94 mg/mL (5.60 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8873 mL 14.4367 mL 28.8734 mL
    5 mM 0.5775 mL 2.8873 mL 5.7747 mL
    10 mM 0.2887 mL 1.4437 mL 2.8873 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.60%

    COA (243 KB) RP-HPLC (252 KB) MS (221 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.8873 mL 14.4367 mL 28.8734 mL 72.1834 mL
    5 mM 0.5775 mL 2.8873 mL 5.7747 mL 14.4367 mL
    H2O 10 mM 0.2887 mL 1.4437 mL 2.8873 mL 7.2183 mL
    15 mM 0.1925 mL 0.9624 mL 1.9249 mL 4.8122 mL
    20 mM 0.1444 mL 0.7218 mL 1.4437 mL 3.6092 mL
    25 mM 0.1155 mL 0.5775 mL 1.1549 mL 2.8873 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    RGD Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RGD99896-85-2IntegrinInhibitorinhibitorinhibit

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    製品名:
    RGD
    製品番号:
    HY-P0278
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