2. Cytoskeleton
  3. Integrin
  4. RGD

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

CAS No. : 99896-85-2

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 8 publication(s) in Google Scholar

Other Forms of RGD:

RGD Related Antibodies

Top Publications Citing Use of Products

    RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    RGD (0.2 mg/mL) was used to immobilize RAW264.7 cells on the hydrogel and minimize cell leakage during operation.

    RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    With or without RGD (0.2 mg/mL) modification, the numbers of RAW264.7 cells in the medium before and after loading and the percentage of cells loaded into the iMASSAGE device were shown.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) significantly ameliorated the prostate volume and the prostate weight-to-body weight ratio of testosterone (TP)-induced BPH mice.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) strikingly increased global succinylation levels in testosterone (TP)-induced BPH mice.

    RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) therapy significantly ameliorated prostate hyperplasia of testosterone (TP)-induced BPH mice, as evidenced by the absence of morphological abnormalities such as excessive proliferation in the glandular epithelium, focal intraluminal papillary folds, and secretion-filled distended ducts.

    View All Integrin Isoform Specific Products:

    View All Isoforms
    αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

    IC50 & Target

    Integrin[1]
    Cellular Effect
    Cell Line Type Value Description References
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    Platelet IC50
    319 3
    Compound: RGD
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
    		[PMID: 25457125]
    In Vitro

    RGD is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    RGD Related Antibodies
    분자량

    346.34

    화학식

    C12H22N6O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Arg-Gly-Asp
    Sequence Shortening

    RGD
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    용액&용해도
    In Vitro: 

    H2O : 10 mg/mL (28.87 mM; Need ultrasonic)

    DMSO : 1.94 mg/mL (5.60 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8873 mL 14.4367 mL 28.8734 mL
    5 mM 0.5775 mL 2.8873 mL 5.7747 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    순도&문서

    Purity: 99.60%

    SDS (393 KB)

    COA (243 KB) RP-HPLC (252 KB) MS (221 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.8873 mL 14.4367 mL 28.8734 mL 72.1834 mL
    5 mM 0.5775 mL 2.8873 mL 5.7747 mL 14.4367 mL
    H2O 10 mM 0.2887 mL 1.4437 mL 2.8873 mL 7.2183 mL
    15 mM 0.1925 mL 0.9624 mL 1.9249 mL 4.8122 mL
    20 mM 0.1444 mL 0.7218 mL 1.4437 mL 3.6092 mL
    25 mM 0.1155 mL 0.5775 mL 1.1549 mL 2.8873 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    RGD Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RGD99896-85-2IntegrinInhibitorinhibitorinhibit

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    상품명:
    RGD
    Cat. No.:
    HY-P0278
    수량:
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    SAFETY DATA SHEET (SDS)

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