2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0343
    Sarafloxacin 98105-99-8 98%
    Sarafloxacin (A-56620) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa.
    Sarafloxacin
  • HY-B1130
    Isoxicam 34552-84-6 99.83%
    Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders.
    Isoxicam
  • HY-B1265
    Hydrocortisone 17-valerate 57524-89-7 98.0%
    Hydrocortisone 17-valerate (Cortisol 17-valerate) is a 17α-ester derivative of Hydrocortisone (HY-N0583), an endogenous glucocorticoid with anti-inflammatory activity. Hydrocortisone 17-valerate can be used for research on skin inflammation.
    Hydrocortisone 17-valerate
  • HY-B1355
    Oxyphenbutazone monohydrate 7081-38-1 98.02%
    Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis.
    Oxyphenbutazone monohydrate
  • HY-B1471
    Fluorometholone acetate 3801-06-7 98.54%
    Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research.
    Fluorometholone acetate
  • HY-B1675
    Levalbuterol 34391-04-3 99.79%
    Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.
    Levalbuterol
  • HY-B2206
    Gefarnate 51-77-4 98%
    Gefarnate is a agent used for the treatment of gastritis and gastric ulcer, and has been proposed for use in the treatment of dry eye syndrome.
    Gefarnate
  • HY-D0237
    Betahistine mesylate 54856-23-4 99.90%
    Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine mesylate is used for the study of rheumatoid arthritis (RA).
    Betahistine mesylate
  • HY-D0984
    TMRM 115532-49-5 98%
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
    TMRM
  • HY-D1065
    NIR-H2O2 1392488-04-8 98%
    NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H2O2 with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H2O2 in living cells and mice.
    NIR-H2O2
  • HY-D1158
    HKOCl-4m 2031170-88-2 98.27%
    HKOCl-4m is a selective and mitochondria-targeting rhodol-based fluorescent probe for monitoring mitochondrial hypochlorous acid (HOCl).
    HKOCl-4m
  • HY-N0430
    Coptisine 3486-66-6 98%
    Coptisine is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine is a reversible, uncompetitive IDO inhibitor with a Ki of 5.8 μM and an IC50 of 6.3 μM. Coptisine suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine can be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease.
    Coptisine
  • HY-N0592
    Demethyleneberberine 25459-91-0 ≥98.0%
    Demethyleneberberine is a blood-brain barrier-permeable antioxidant. Demethyleneberberine exerts antioxidant effects by targeting mitochondria, activates the AMPK signaling pathway to regulate lipid metabolism, and inhibits inflammation-related pathways such as NF-κB and MAPK. Demethyleneberberine can be used in the research of inflammatory and other diseases.
    Demethyleneberberine
  • HY-N0759
    Acetylcorynoline 18797-80-3 ≥99.0%
    Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, and has anti-inflammatory properties.
    Acetylcorynoline
  • HY-N0764
    Isobergapten 482-48-4 99.37%
    Isobergapten is an allelopathic inhibitor isolated from seeds of Hevacleum laciniatum.
    Isobergapten
  • HY-N0811
    Anemarsaponin B 139051-27-7 99.43%
    Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .
    Anemarsaponin B
  • HY-N0915
    Melittoside 19467-03-9 99.01%
    Melittoside is a natural compound.
    Melittoside
  • HY-N0940
    Batatasin I 51415-00-0 99.0%
    Batatasin I is a natural product that can be isolated from tuberous roots of Dioscorea batatas, with antifungal activity and anti-inflammatory effects.
    Batatasin I
  • HY-N1022
    11-Hydroxytephrosin 72458-85-6 ≥98.0%
    11-Hydroxytephrosin is a potent NF-κB inhibitor with an IC50 of 0.19 μM or 4.21 μM. 11-Hydroxytephrosin is isolated from A. fruticosa. 11-Hydroxytephrosin inhibits the activation of NF-κB. 11-Hydroxytephrosin can be used in research related to cervical cancer and inflammatory diseases.
    11-Hydroxytephrosin
  • HY-N1074
    Warangalone 4449-55-2
    Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 of 3.5 μM.
    Warangalone
Cat. No. Product Name / Synonyms Application Reactivity