1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Levalbuterol

Levalbuterol (Synonyms: (R)-Albuterol; (R)-Salbutamol; Levosalbutamol)

Cat. No.: HY-B1675
Handling Instructions

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.

For research use only. We do not sell to patients.

Levalbuterol Chemical Structure

Levalbuterol Chemical Structure

CAS No. : 34391-04-3

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Description

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].

In Vitro

Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1].
Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1].

RT-PCR[1]

Cell Line: Murine Club (MTCC) cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased 11β-HSD1 mRNA expression selectively.
In Vivo

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3].

Animal Model: C57BL/6 female mice with a pulmonary allergic model[3]
Dosage: 1 mg/kg
Administration: Subcutaneous injection; 1 mg/kg; 14 days
Result: Decreased pulmonary inflammation after OVA sensitization.
Molecular Weight

239.31

Formula

C₁₃H₂₁NO₃

CAS No.

34391-04-3

SMILES

CC(C)(NC[[email protected]@H](C1=CC=C(C(CO)=C1)O)O)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Levalbuterol(R)-Albuterol(R)-SalbutamolLevosalbutamolAdrenergic ReceptorBeta Receptorasthmachronicobstructive pulmonaryCOPDbronchodilatorInhibitorinhibitorinhibit

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