1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Levalbuterol

Levalbuterol  (Synonyms: (R)-Albuterol; (R)-Salbutamol; Levosalbutamol)

Cat. No.: HY-B1675
Handling Instructions

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.

For research use only. We do not sell to patients.

Levalbuterol Chemical Structure

Levalbuterol Chemical Structure

CAS No. : 34391-04-3

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Description

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].

In Vitro

Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1].
Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Murine Club (MTCC) cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased 11β-HSD1 mRNA expression selectively.
In Vivo

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice with a pulmonary allergic model[3]
Dosage: 1 mg/kg
Administration: Subcutaneous injection; 1 mg/kg; 14 days
Result: Decreased pulmonary inflammation after OVA sensitization.
Clinical Trial
Molecular Weight

239.31

Formula

C13H21NO3

CAS No.
SMILES

CC(C)(NC[C@@H](C1=CC=C(C(CO)=C1)O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Levalbuterol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Levalbuterol
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