2. Signaling Pathways
  3. Cytoskeleton
  4. Arp2/3 Complex
  5. Arp2/3 Complex Inhibitor

Arp2/3 Complex Inhibitor

Arp2/3 Complex Inhibitors (21):

Cat. No. Product Name Effect Purity
  • HY-N6682
    Cytochalasin D
    		Inhibitor 99.76%
    Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap.
  • HY-16926
    CK-666
    		Inhibitor 99.95%
    CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
  • HY-16931
    SMIFH2
    		Inhibitor 99.08%
    SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton.
  • HY-16929
    Latrunculin A
    		Inhibitor 98.9%
    Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.
  • HY-NP208
    Myelin Basic Protein (Porcine)
    		Inhibitor
    Myelin Basic Protein (Porcine), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin Basic Protein (Porcine) mediates interactions with actin and tubulin and effect of post-translational modifications.
  • HY-16927
    CK-869
    		Inhibitor 99.84%
    CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.
  • HY-12534
    Wiskostatin
    		Inhibitor 99.87%
    Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC50 value of 20.7 μM and a potent inhibitor of clathrin-mediated endocytosis with an IC50 value of 6.9 μM. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line.
  • HY-114657A
    Benproperine phosphate
    		Inhibitor 99.93%
    Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.
  • HY-15892
    CK-636
    		Inhibitor 99.94%
    CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration.
  • HY-18931
    (Rac)-NSC305787
    		Inhibitor 99.29%
    NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.
  • HY-18931A
    (Rac)-NSC305787 hydrochloride
    		Inhibitor 98.18%
    NSC305787 hydrochloride is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.
  • HY-111578
    BDP-13176
    		Inhibitor 99.25%
    BDP-13176 is a potent fascin 1 inhibitor, with a Kd of 90 nM and an IC50 of 240 nM. BDP-13176 has potential as an anti-metastatic agent.
  • HY-P1045
    187-1, N-WASP inhibitor
    		Inhibitor 99.34%
    187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.
  • HY-124689
    TR-100
    		Inhibitor 99.0%
    TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion.
  • HY-123312
    CK-548
    		Inhibitor
    CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection.
  • HY-161011
    Spire2-FMN2 PPI-IN-1
    		Inhibitor
    Spire2/FMN2 PPI-IN-1 (Compound 13) is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC50 of 62 μM. Spire2/FMN2 PPI-IN-1 has affinity for KIND2, with a Kd of 87.7 μM, and does not inhibit KIND1. Spire2/FMN2 PPI-IN-1 can be used for the development of chemical probes for the Spire2-FMN2 interaction.
  • HY-161011A
    Spire2-FMN2 PPI-IN-1 dihydrochloride
    		Inhibitor 98.99%
    Spire2/FMN2 PPI-IN-1 (Compound 13) dihydrochloride is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC50 of 62 μM. Spire2/FMN2 PPI-IN-1 dihydrochloride has affinity for KIND2, with a Kd of 87.7 μM, and does not inhibit KIND1. Spire2/FMN2 PPI-IN-1 dihydrochloride can be used for the development of chemical probes for the Spire2-FMN2 interaction.
  • HY-164677
    PLH1215
    		Inhibitor 99.98%
    PLH1215 is a compound used to regulate, limit, or inhibit the expression of AVIL (advillin), which can be utilized in cancer research.
  • HY-126989
    19-O-Acetylchaetoglobosin A
    		Inhibitor
    19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells.
  • HY-P1045A
    187-1, N-WASP inhibitor TFA
    		Inhibitor
    187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.