1. Epigenetics
    TGF-beta/Smad
  2. PKC

NSC305787 hydrochloride 

Cat. No.: HY-18931A Purity: 98.70%
Handling Instructions

NSC305787 hydrochloride is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.

For research use only. We do not sell to patients.

NSC305787 hydrochloride Chemical Structure

NSC305787 hydrochloride Chemical Structure

CAS No. : 53868-26-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of NSC305787 hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

NSC305787 hydrochloride is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. Target: PKC in vitro: NSC305787 demonstrates a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis. Both NSC305787 and NSC668394 inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels. Both NSC305787 (P = 0.003) significantly inhibits the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay. [1] in vivo: NSC305787 cause reduced cell motility phenotypes in zebrafish. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0752 mL 10.3758 mL 20.7516 mL
5 mM 0.4150 mL 2.0752 mL 4.1503 mL
10 mM 0.2075 mL 1.0376 mL 2.0752 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

481.89

Formula

C₂₅H₃₁Cl₃N₂O

CAS No.

53868-26-1

SMILES

OC(C1NCCCC1)C2=CC(C3(C4)CC5CC4CC(C5)C3)=NC6=C(Cl)C=C(Cl)C=C26.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 8 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
NSC305787 hydrochloride
Cat. No.:
HY-18931A
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