1. Cytoskeleton
  2. Arp2/3 Complex
  3. 187-1, N-WASP inhibitor TFA

187-1, N-WASP inhibitor TFA 

Cat. No.: HY-P1045A
Handling Instructions

187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.

For research use only. We do not sell to patients.

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187-1, N-WASP inhibitor TFA Chemical Structure

187-1, N-WASP inhibitor TFA Chemical Structure

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Description

187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].

Molecular Weight

1898.13

Formula

C₉₈H₁₂₃F₃N₁₈O₁₈

Sequence

Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}]

Sequence Shortening

Cyclo[QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}-QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

187-1, N-WASP inhibitorArp2/3 ComplexActin-related protein 2/3 complexN-WASPPIP2cyclicpeptideArp2Arp3autoinhibitedInhibitorinhibitorinhibit

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187-1, N-WASP inhibitor TFA
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HY-P1045A
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